Results 111 to 120 of about 2,355,447 (305)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Description of the elasto-plastic material routine SGDI [PDF]

, 2015
We describe the FORTRAN subroutine SGDI for rate-independent deviatoric plasticity with von Mises yield criterion and isotropic hardening, which corresponds to the VM23 material type in the EUROPLEXUS code (abbreviated as EPX in the following).
Aune, Vegard, Casadei, Folco, Valsamos, Georgios, Larcher, Martin   +3 more
core   +1 more source

Routinization in Nursing Care: An Integrated Review

Iranian Journal of Nursing and Midwifery Research
Background: There is growing evidence that routinization in nursing care is a concerning issue that directly affects the quality of nursing care and nurses’ ability to be creative and innovative in care, flexibility, and ability to provide individualized
Reza Mohammad pourhodki, Zahra-Sadat Manzari, Javad Moghri, Abbas Heydari   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Diagnosis of antiphospholipid syndrome in routine clinical practice. [PDF]

, 2013
The updated international consensus criteria for definite antiphospholipid syndrome (APS) are useful for scientific clinical studies. However, there remains a need for diagnostic criteria for routine clinical use.
Hills, J, Cohen, H, Gardiner, C, Machin, SJ   +3 more
core  

Urinary Red Blood Cell Distribution for Detection of Glomerular Hematuria: A Biopsy-Based Comparison with Direct Microscopy

Diagnostics
Background: Differentiating glomerular from non-glomerular hematuria remains challenging. Automated urine analyzers with red blood cell (RBC) discrimination algorithms may provide an adjunct to conventional urine microscopy.
Nuttasith Larpparisuth, Paweena Kanogpotjananont, Kanit Reesukumal, Methawoot Khemmongkol, Gahwin Ruchikajorndech, Chanchira Janwijit, Peenida Skulratanasak   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Validation of a long-read 16S rRNA-gene sequencing approach for analysis of clinical samples and bacterial identification in a routine clinical laboratory

Frontiers in Microbiology
BackgroundCurrently, microbiological diagnosis relies heavily on classical culture-based techniques, which have notable limitations. These methods often struggle with detecting non-culturable or slow-growing microorganisms and can yield negative results ...
Otto Van de gaer, Reinoud Cartuyvels, Timo Froyen, Petra Hilkens, Koen Magerman, Koen Magerman, Steven Martens, Britt Van Meensel, Jozef Dingemans   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source