Results 71 to 80 of about 3,578,337 (334)

Diagnosis of fetal non‐chromosomal abnormalities on routine ultrasound examination at 11–13 weeks' gestation

Ultrasound in Obstetrics and Gynecology, 2019
To examine the performance of the routine 11–13‐week scan in detecting fetal non‐chromosomal abnormalities.
A. Syngelaki, A. Hammami, S. Bower, V. Zidere, R. Akolekar, K. Nicolaides   +5 more
semanticscholar   +1 more source

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis [PDF]

, 2020
Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening.
Carreto, Luis, Chalmers, James D., Donovan, Jackie, Fardon, Tom, Finch, Simon, Furrie, Elisabeth, Loebinger, Michael, Morrison, Meghan, Tan, Gan Liang, Wilson, Robert   +9 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Diagnostic Accuracy of Optic Nerve Ultrasonography and Ophthalmoscopy in Prediction of Elevated Intracranial Pressure

Archives of Academic Emergency Medicine, 2018
Introduction: Elevated intracranial pressure (ICP) is a major and potentially lethal disorder in patients admitted to the emergency department (ED). Several methods are being used to investigate for elevated ICP.
Keihan Golshani, Mehdi Ebrahim zadeh, Ziba Farajzadegan, Fariborz Khorvash   +3 more
doaj   +1 more source

Implementation of thyroid-related patient-reported outcomes in routine clinical practice

Frontiers in Endocrinology, 2022
Patient-reported outcomes (PROs) are increasingly used in clinical practice to improve clinical care. Multiple studies show that systematic use of PROs can enhance communication with patients and improve patient satisfaction, symptom management and ...
Per Karkov Cramon, Per Karkov Cramon, Jakob Bue Bjorner, Jakob Bue Bjorner, Mogens Groenvold, Mogens Groenvold, Victor Brun Boesen, Steen Joop Bonnema, Laszlo Hegedüs, Ulla Feldt-Rasmussen, Ulla Feldt-Rasmussen, Åse Krogh Rasmussen, Torquil Watt, Torquil Watt   +13 more
doaj   +1 more source

Primary Care Staff's Views and Experiences Related to Routinely Advising Patients about Physical Activity. A Questionnaire Survey [PDF]

, 2006
Background: United Kingdom public health policy has recently re-emphasised the role of primary health care professionals in tackling increasing levels of physical inactivity within the general population.
A Steptoe, A Steptoe, A Taylor, Ann Kerr, BA Swinburn, CR Elley, DA Lawlor, Department of Health, Physical Activity, Health Improvement and Prevention, DO Clark, Edwin van Teijlingen, EG Eakin, FCL Bull, Flora Douglas, J McKenna, J McKenna, J Naidoo, JE Walsh, L Green, M Fitzpatrick, M Hillsdon, Mental Health Foundation, MG Goldstein, N Mutrie, Nicola Torrance, O Morgan, R Ashenden, R Schwarzer, RE Glasgow, RE Glasgow, S Hardcastle, Scottish Executive, Scottish Executive Health Department, Scottish Forum for Public Health Medicine, Scottish Intercollegiate Guidelines Network (SIGN), Scottish Intercollegiate Guidelines Network (SIGN), Serena Meloni, World Health Organization (WHO)   +36 more
core   +4 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Space flight research relevant to health, physical education, and recreation: With particular reference to Skylab's life science experiments [PDF]

, 1979
Data collected in the Skylab program relating to physiological stresses is presented. Included are routine blood measures used in clinical medicine as research type endocrine analyses to investigate the metabolic/endocrine responses to weightlessness ...
Heusner, W. W., Vanhuss, W. D.
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source