Results 81 to 90 of about 2,355,447 (305)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A Motivational Account for Post-Acceptance Routine and Innovative Use: Introducing the Concept of Tri-Dimensional Intrinsic Motivation [PDF]
, 2009 We conceptualize two distinct post-acceptance usage behaviors: (1) routine use (RTN) refers to the use of information system (IS) consistent with normal work processes and (2) innovative use (INV) means users’ applying system features in novel ways ...
Li, Xixi, Rai, Arun, Hsieh, J.J. Po-An
core
The Wonderful, Magnanimous, Spectacular and Possible World of Traveling Circuses in Brazil [PDF]
BAR: Brazilian Administration Review, 2016 This paper aims to examine the everyday management of traveling circuses in Brazil by looking for the practices and strategies that allow them to survive over time.
Ana Rosa Camillo Aguiar +2 more
doaj
LIABILITY OF CREDIT INSTITUTIONS IN THE CONTEXT OF BLOCKING SANCTIONS: LEGAL ASPECTS AND JUDICIAL PRACTICE [PDF]
Legal BulletinThe relevance of this study is due to the increased control by European and American correspondent banks over monetary transactions from the Russian Federation, which often leads to the blocking of funds coming from Russia by placing them in special ...
KOSTIKOVA G.V.
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Implementing an aim-based outcome measure in a psychoanalytic child psychotherapy service: Insights, experiences and evidence [PDF]
, 2014 In this paper, we describe the use of an aim-based outcome measure used in routine outcome monitoring of child and adolescent psychotherapy within a child and adolescent mental health service. We present empirical evidence drawn from a cohort of 34 child
Helen Muller +14 more
core +1 more source
Future InternetEnd-User Development has been proposed over the years to allow end users to control and manage their Internet of Things-based environments, such as smart homes.
Luca Cotti +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source