Results 151 to 160 of about 1,244 (224)

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Structural Evolution and Oxygen Evolution Performance of NiFe‐Based Electrocatalysts in Phosphate‐Containing Electrolytes at Non‐Extreme pH

Angewandte Chemie, EarlyView.
Phosphate acts as a selective interfacial probe of nickel–iron oxide oxygen evolution electrocatalysts at non‐extreme pH. It reversibly suppresses Ni‐centered oxidation and activity, whereas cycling through the Ni reduction region promotes irreversible catalyst loss.
Hiroki Komiya, Keisuke Obata, Joonbaek Jang, Samuele Lasagna, Sotiris Tsatsos, Lichen Bai, Andrea Martini, Timon Wagner, Janis Timoshenko, Arno Bergmann, Beatriz Roldan Cuenya, Kazuhiro Takanabe   +11 more
wiley   +2 more sources

Tracing Structural Distortions and Orbital Population During Spin‐Crossover in Transition Metal Complexes via Ligand K‐edge Spectroscopy

Angewandte Chemie International Edition, EarlyView.
Nitrogen K‐edge XAS and RIXS reveal signatures of structural and electronic relaxation in the photo‐induced spin‐crossover cascade of iron‐(II)‐tris(bipyridine). Oscillations of the 1s→π∗$1{\rm s} \rightarrow \pi ^*$ transition energy are correlated with the transient elongation of the Fe─N bonds.
Sebastian Eckert, Benjamin E. Van Kuiken, Andre Al Haddad, Vinícius Vaz da Cruz, Wagner Ribeiro da Silva Neto, Leo Cordsmeier, Annette Pietzsch, Mattis Fondell, Yi‐Ping Chang, Natalia Gerasimova, Justine Schlappa, Robert Carley, Giuseppe Mercurio, Teguh Citra Asmara, Cammille Carinan, Gregor Knopp, Kirsten Schnorr, Xinhua Xie, Antoine Sarracini, Jonas Knurr, Eloisa F. Manetti, Suddhasattwa Mandal, Loïc L. C. Bassement, Christoph Bostedt, Andreas Scherz, Alexander Föhlisch   +25 more
wiley   +1 more source

Routing and spectrum allocation in static fiber optic networks

, 2016
The continuous growth of demand on internet requires high speed connection and larger capacity on telecommunication networks. In order to satisfy the day-by-day increasing connection requests, a new modulation technique named Orthogonal Frequency Division Multiplexing (OFDM), which promises faster connection and better usage of optical spectrum has ...
openaire   +2 more sources

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Potential for Carotenoid and Other Bioproducts Production by a Brazilian Dunaliella salina Isolate Using a High Photon Flux Density Strategy

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Dunaliella species are among the most significant biological sources of carotenoids, notably beta‐carotene. Given that chemical synthesis offers a more cost‐effective alternative to biotechnological cultivation, optimizing production strategies is essential for economic viability.
Camylle Guimarães Scheliga, Izabela Queiroz Silva, Lucielen Oliveira Santos, Cláudia Maria Luz Lapa Teixeira   +3 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Innovation Pathways to Carbon Efficiency: Disentangling the Effects of AI, R&D, and Clean Energy Blessings on U.S. Environmental Sustainability

Business Strategy and the Environment, EarlyView.
ABSTRACT The United States (U.S.) faces challenges in achieving its ambitious net‐zero carbon emissions target by 2050, with current emissions having fallen by less than 1% in 2024. Despite an investment of $500 billion in low‐carbon resources while holding the second‐largest green technology patent portfolio globally, it is further imperative to ...
Md Zubair Ahmad, Jewel Rana, Mohammad Fakhrul Islam, Md Nazmul Islam Jihad, Md. Rashed, Md. Kamal Uddin   +5 more
wiley   +1 more source