Results 41 to 50 of about 11,548 (261)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Entanglement Routing in Quantum Networks: A Comprehensive Survey

IEEE Transactions on Quantum Engineering
Entanglement routing in near-term quantum networks consists of choosing the optimal sequence of short-range entanglements to combine through swapping operations to establish end-to-end entanglement between two distant nodes.
Amar Abane, Michael Cubeddu, Van Sy Mai, Abdella Battou   +3 more
doaj   +1 more source

Smart Routing Management Framework Exploiting Dynamic Data Resources of Cross-Layer Design and Machine Learning Approaches for Mobile Cognitive Radio Networks: A Survey

IEEE Access, 2020
The concept of Cognitive Radio (CR) has emerged as a practical solution to solve the issue of the fixed spectrum and bandwidth scarcity in wireless communication.
Qusay Medhat Salih, Md. Arafatur Rahman, Fadi Al-Turjman, Zafril Rizal M. Azmi   +3 more
doaj   +1 more source

Design of a Self-Organizing Routing Protocol for Underwater Wireless Sensor Networks Based on Location and Energy Information

Journal of Marine Science and Engineering, 2023
Underwater wireless sensor networks (UWSNs) are significantly different from terrestrial sensor networks in the following aspects: low bandwidth, high latency, variable topology, limited battery, low processing power and so on.
Weizhen Guo, Min Zhu, Bo Yang, Yanbo Wu, Xinguo Li   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Reinforcement Learning-Based Routing Protocol to Minimize Channel Switching and Interference for Cognitive Radio Networks

Complexity, 2020
In the existing network-layered architectural stack of Cognitive Radio Ad Hoc Network (CRAHN), channel selection is performed at the Medium Access Control (MAC) layer. However, routing is done on the network layer.
Tauqeer Safdar Malik, Mohd Hilmi Hasan
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

HPIM‐DM: A fast and reliable dense‐mode multicast routing protocol

IET Networks, 2023
The Hard‐state Protocol Independent Multicast—Dense Mode (HPIM‐DM) multicast routing protocol is proposed. HPIM‐DM is a hard‐state version of PIM‐DM that overcomes its poor convergence times and lack of resilience to replay attacks.
Pedro Oliveira, Alexandre Silva, Rui Valadas   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source