Results 51 to 60 of about 226,487 (336)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Source-specific routing [PDF]

, 2015
Source-specific routing (not to be confused with source routing) is a routing technique where routing decisions depend on both the source and the destination address of a packet.
Boutier, Matthieu, Chroboczek, Juliusz
core   +3 more sources

Routing over QUIC: Bringing transport innovations to routing protocols [PDF]

arXiv, 2023
By combining the security features of TLS with the reliability of TCP, QUIC opens new possibilities for many applications. We demonstrate the benefits that QUIC brings for routing protocols. Current Internet routing protocols use insecure transport protocols. BGP uses TCP possibly with authentication. OSPF uses its own transport protocol above plain IP.
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A Novel Secure Routing Protocol——Multi-Next Hop Routing Protocl Based on Node Potential

Dianxin kexue, 2014
Routing protocol is the core network protocol. It is very important to enhancing network availability and security through improving the routing protocol. Based on the research of routing protocol and security mechanism, the concepts of routing potential
Julong Lan, Jianhui Zhang, Yanhong Wang, Hailong1 Ma, Youjun1 Bu   +4 more
doaj   +2 more sources

Performance Analysis of DTN Using Level Signal Priority Epidemic Routing Protocol

Emitter: International Journal of Engineering Technology, 2016
A DTN architecture consists of several nodes that are connected with high dynamic topology. The routing protocol is an important part which determine the DTN performance system.
Ahmad Zainudin, Amang Sudarsono, Kevin Prima Pambudi   +2 more
doaj   +3 more sources

Weight-Based PA-GPSR Protocol Improvement Method in VANET

Sensors, 2023
Vehicle Ad-hoc network (VANET) can provide technical support and solutions for the construction of intelligent and efficient transportation systems, and the routing protocol directly affects the efficiency of VANET. The rapid movement of nodes and uneven
Wenzhu Zhang, Leilei Jiang, Xi Song, Zhengyuan Shao   +3 more
doaj   +1 more source

Sigma Routing Metric for RPL Protocol [PDF]

Sensors, 2018
This paper presents the adaptation of a specific metric for the RPL protocol in the objective function MRHOF. Among the functions standardized by IETF, we find OF0, which is based on the minimum hop count, as well as MRHOF, which is based on the Expected Transmission Count (ETX). However, when the network becomes denser or the number of nodes increases,
Luis Fernández, Paul Sanmartin, Paul Sanmartin, Aldo Rojas, Karen Avila, Sebastian Valle, Daladier Jabba   +6 more
openaire   +5 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

INTRODUCTION TO ROUTING PROTOCOLS

INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY, 2014
In this era of communication network, we can access any website or contact any person with the help of internet or telephone anywhere in the world without knowing where the website is hosted and without knowing where the person is located. This all is done within a few seconds very efficiently. But the question comes out how it is done?
Nikhil Kumar, Shah Singh, Sahil Kumar, Jagdeep Singh   +3 more
openaire   +3 more sources