Results 311 to 320 of about 2,950,439 (379)

Unveiling Structural Heterogeneity and Evolutionary Adaptations of Heteromultimeric Bacterioferritin Nanocages

open access: yesAdvanced Science, EarlyView.
This study explores the structural heterogeneity and evolutionary adaptations of heteromultimeric bacterioferritins. Hetero‐Bfrs, evolved from either a homo‐Bfr or Ftn by gene duplications, differ from homo‐Bfrs substantially in the mechanisms underpinning iron oxidation and reduction despite high similarity in overall structure.
Yingxi Li   +5 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

open access: yesAdvanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin   +21 more
wiley   +1 more source

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

open access: yesAdvanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian   +10 more
wiley   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui   +17 more
wiley   +1 more source

Adaptive Jamming Mitigation for Clustered Energy-Efficient LoRa-BLE Hybrid Wireless Sensor Networks. [PDF]

open access: yesSensors (Basel)
Del-Valle-Soto C   +5 more
europepmc   +1 more source

Progress and Perspectives in 2D Piezoelectric Materials for Piezotronics and Piezo‐Phototronics

open access: yesAdvanced Science, EarlyView.
This review examines advancements in 2D materials, focusing on their applications in piezotronics and piezo‐phototronics. It discusses key materials like TMDs, h‐BN, and phosphorene, highlighting their unique mechanical, electronic, and optical properties.
Fengyi Pang   +6 more
wiley   +1 more source

Optimization of network device hardening in a multivendor environment. [PDF]

open access: yesSci Rep
Imoukhuede AB   +3 more
europepmc   +1 more source

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

open access: yesAdvanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini   +8 more
wiley   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

open access: yesAdvanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang   +8 more
wiley   +1 more source

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