Results 51 to 60 of about 134,397 (274)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

EVALUATION AND COMPARISON OF EMERGING ENERGY EFFICIENT ROUTING PROTOCOLS IN MANET [PDF]

open access: yesICTACT Journal on Communication Technology, 2010
The routing in Mobile Ad Hoc Network (MANET) consumes huge amount of power and bandwidth and undergoes frequent topology changes to which it must adjust quickly. Energy efficient routing protocols have an important role in MANET.
Getsy S Sara   +2 more
doaj  

A Taxonomy for Routing Protocols in Mobile Ad Hoc Networks [PDF]

open access: yes, 1999
A Mobile Ad hoc NETwork (manet) is a mobile, multi-hop wireless network which is capable of autonomous operation. It is characterized by energy-constrained nodes, bandwidth-constrained, variable-capacity wireless links and dynamic topology, leading ...
Feeney, Laura Marie
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Performance Evaluation of Important Ad Hoc Network Protocols

open access: yesEURASIP Journal on Wireless Communications and Networking, 2006
A wireless ad hoc network is a collection of specific infrastructureless mobile nodes forming a temporary network without any centralized administration.
Ahmed S, Alam MS
doaj   +2 more sources

Performance Comparisons of Geographic Routing Protocols in Mobile Ad Hoc Networks

open access: yes, 2015
Geographic routing protocols greatly reduce the requirements of topology storage and provide flexibility in the accommodation of the dynamic behavior of mobile ad hoc networks. This paper presents performance evaluations and comparisons of two geographic
Talarico, Salvatore   +2 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Survey on cluster-based routing protocols for cognitive radio sensor networks

open access: yesTongxin xuebao, 2018
Routing protocols could achieve efficient convergecast transmission of sensed data in cognitive radio sensor network (CRSN),and it is of vital importance for the whole network performance.In particular,cluster-based routing protocols could further lower ...
Jihong WANG, Wenxiao SHI
doaj   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

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