Results 51 to 60 of about 12,398 (259)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Etes-vous pret? Partez! – The Late Start of Women Rowers

Physical Culture and Sport: Studies and Research, 2018
The aim of our study is to show the development of women's rowing and competition, as well as the reasons for its slow spread, taking into account the so called decisive era, the social environment, which, although in various ways, has greatly influenced
Alliquander Anna, Tibori Tímea
doaj   +1 more source

Lumbar Intervertebral Disc Degeneration Does Not Affect Muscle Synergy for Rowing Activities

Applied Bionics and Biomechanics, 2021
Rowers with disc degeneration may have motor control dysfunction during rowing. This study is aimed at clarifying the trunk and lower extremity muscle synergy during rowing and at comparing the muscle synergy between elite rowers with and without lumbar ...
Chie Sekine, Naoto Matsunaga, Yu Okubo, Mika Hangai, Koji Kaneoka   +4 more
doaj   +1 more source

Detection of Row-sparse Matrices with Row-structure Constraints [PDF]

ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2019
An underdetermined multi-measurement vector linear regression problem is considered where the parameter matrix is row-sparse and where an additional constraint fixes the number of nonzero elements in the active rows. Even if this additional constraint offers side structure information that could be exploited to improve the estimation accuracy, it is ...
Gregoratti, David, Buelga, Carlos, Mestre, Xavier   +2 more
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Effects of a Flywheel-Based Post-Activation Performance Enhancement Warm-Up Versus a Traditional Rowing Ergometer Warm-Up on 500 m Rowing and Neuromuscular Performance

European Journal of Human Movement
Post-activation performance enhancement using flywheel exercises offers substantial immediate consequences on neuromuscular responses and mechanical adaptations.
Piyathida Thongchai, Nareerat Koedsiri, Sasina Johansen, Siriwanna Manosukhumnon, Adithep Santalunai, Rodrigo Zacca, Dang Van Dung, Phornpot Chainok   +7 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The Effect of Neuromuscular Fatigue on the Spatiotemporal Coordination of Rowing

Applied Sciences
Within rowing, lower back disorders (LBDs) are common, but the mechanisms underpinning LBDs are poorly understood. Considering this, it is essential to understand how coordination and motor control change under different constraints such as ergometer ...
Carl J. Alano, Chris L. Vellucci, Aurora Battis, Shawn M. Beaudette   +3 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source