Results 51 to 60 of about 13,762 (186)

Validity of ROX index in prediction of risk of intubation in patients with COVID-19 pneumonia

Acute critical care, 2020
Introduction: One important concern during the management of COVID-19 pneumonia patients with acute hypoxemic respiratory failure is early anticipation of the need for intubation. ROX is an index that can help in identification of patients with low and those with high risk of intubation. So, this study was planned to validate the diagnostic accuracy of
Suliman, Lucy, Abdelgawad, Taha, Farrag, Nesrine, Abdelwahab, Heba   +3 more
openaire   +3 more sources

To study the effect of proning the patient on ROX index in Covid patients on HFNC

Panacea Journal of Medical Sciences, 2022
Background: The study aimed to determine the outcome of prone position on oxygenation by studying the ROX index of the COVID 19 patients.Materials and Methods: This study was conducted as a prospective observational study on COVID 19 patients admitted in HDU and ICU requiring HFNC at Gandhi Medical College and Hamidia hospital Bhopal which is a ...
Arun Suresh, Shraddha Gangele, Krishnaraj Pai, Ruchi Tandon, Yuvaraj Patil, Rahul Belgaonkar   +5 more
openaire   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The utility value of ROX index and modified ROX index in determining the efficiency of HFNC in children admitted with respiratory distress

International Journal of Contemporary Pediatrics
Background: The ROX index is defined as the ratio of SpO2/FiO2 to respiratory rate. The modified ROX index or ROX-HR index is defined as the ratio of ROX index/heart rate×100. The aim of the study was to determine the utility of the ROX index and the modified ROX index as predictors of initiation and efficiency of HFNC in children admitted with ...
Sravni Kolla, Raviteja Meda, Lokeswari Balleda, Chandrasekhara Reddy Thimmapuram   +3 more
openaire   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Prognostic value of the oxygenation index measured during mechanical ventilation and weaning. A retrospective cohort study

Monaldi Archives for Chest Disease
The aim of this study was to investigate the predictive value of the ratio of oxygen saturation (ROX) index calculated during mechanical ventilation (MV) and the weaning period in evaluating readiness to weaning and the success of the spontaneous ...
Esra Eriş, Ayshan Mammadova, Ayşe Taşçı Kara, Aydın Atasoy, Zeynep Sena Solmaz, Gül Gürsel   +5 more
doaj   +1 more source

Comparison of ROX and HACOR scales to predict high-flow nasal cannula failure in patients with SARS-CoV-2 pneumonia

Scientific Reports, 2021
The pandemic of SARSCov2 infection has created a challenge in health services worldwide. Some scales have been applied to evaluate the risk of intubation, such as the ROX and HACOR. The objective of this study is to compare the predictive capacity of the
Carlos Fernando Valencia, Oscar David Lucero, Onofre Casas Castro, Andrey Alexandrovich Sanko, Peter Alfonso Olejua   +4 more
doaj   +1 more source

Utility and timing of the ROX index in the prediction of high flow oxygen therapy failure in acute hypoxemic respiratory failure of infective etiology: a prospective observational study

Monaldi Archives for Chest Disease, 2023
During and following the COVID-19 pandemic, the world has witnessed a surge in high-flow oxygen therapy (HFOT) use. The ability to provide high oxygenation levels with remarkable comfort levels has been the grounds for the same.
Pramod Chaudhari, Pawan Kumar Singh, Manjunath Govindagoudar, Vinod Sharma, Puneet Saxena, Aman Ahuja, Lokesh Lalwani, Dhruva Chaudhry   +7 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source