Results 61 to 70 of about 241,223 (284)

Response-adaptive dose-finding under model uncertainty [PDF]

, 2010
Dose-finding studies are frequently conducted to evaluate the effect of different doses or concentration levels of a compound on a response of interest.
At Bochum, Björn Bornkamp, Frank Bretz, Holger Dette, Jose ́ Pinheiro   +4 more
core   +3 more sources

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Designing and validating an adaptation tool for endometriosis: an exploratory mixed method study protocol

Reproductive Health
Background Endometriosis is a benign and chronic gynecological estrogen-dependent condition. Research findings have highlighted its impact on different aspects of women's lives. Enhancing quality of life and supporting the well-being of those affected is
Sanaz Mollazadeh, Nahid Marvi, Talat Khadivzadeh   +2 more
doaj   +1 more source

Analisis Praktek Keperawatan Medikal Bedah dengan Pendekatan Teori Adaptasi Roy pada Pasien Gangguan Persyarafan di RSUPN dr. Cipto Mangunkusumo Jakarta

Jurnal Kesehatan, 2017
Methods that used in Medical surgical nursing practice were the case study design. It was done by implement nursing care in patients with impaired neurological using Roy's adaptation model.
Pujiarto Pujiarto
doaj   +1 more source

‘People Need to Understand That They Are Stealing From Their Neighbours’: A Critical Media Analysis of the Representations and Resistance Throughout the Robodebt Scheme

Australian Journal of Social Issues, EarlyView.
ABSTRACT The Robodebt scheme issued thousand‐dollar debts to an estimated half a million people who had received social security. The debts were largely inaccurate and illegal, with the aim of improving the federal government's budget. The 2023 Royal Commission into the Robodebt Scheme found that the stigmatising political and public language about ...
Ella Kruger, Phillipa Evans
wiley   +1 more source

Convergence with the reality of the body image term in mastectomised woman: reflexive analysis according to Barnum

Online Brazilian Journal of Nursing, 2008
The nursing theories have an important role in understanding the Nursing practice as a professional tool which brings autonomy and visibility. According to this, the elaboration of a reflexive theoretical study and analysis was chosen based on Barnum ...
Francisco Stélio Sousa, Marcos Venícios de Oliveira Lopes, Ana Fátima Carvalho Fernandes   +2 more
doaj   +2 more sources

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

FACTORS RELATED TO RESILIENCE IN TYPE 2 DIABETES MELLITUS PATIENTS IN DENPASAR BASED ON SELF-CONCEPT MODE OF ROY ADAPTATION MODEL

Belitung Nursing Journal, 2018
Background: Patients with type 2 Diabetes mellitus are impaired both physically and psychologically. Based on preliminary studies carried out in public health centers in Denpasar, Bali, out of 10 patients interviewed, 70% of the patients with type 2 ...
Ni Made Candra Yundarini, Noorhamdani, Heri Kristianto   +2 more
doaj  

Effects of Therapeutic Music on Improving Depressive Symptoms Among Long-Term Care Facility Residents [PDF]

, 2019
Depression is a common mental disorder that can contribute to both physical and psychological suffering (Skinner, 2014). The prevalence rate of depression is especially high among long-term care facility residents (CounsultGeri, 2018; Lolk & Andersen ...
Jin, Yi
core   +2 more sources

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source