Results 161 to 170 of about 2,083,459 (269)

Targeting mitocytosis potentiates mitochondria drug delivery for antimetastasis therapy. [PDF]

Sci Adv
Deng Y, Zhang Y, Jia F, Jiang P, Li L, Huang Y.   +5 more
europepmc   +1 more source

RP rewind

Reinforced Plastics, 2021
openaire   +1 more source

Supercoiled DNA: Structure [PDF]

, 2005
Bowater, RP
core   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Evaluating route preview as an alternative to turn-by-turn navigation in pedestrian mobility. [PDF]

PLoS One
Savino GL, de Bellis E, Kirkham R, Schöning J.   +3 more
europepmc   +1 more source

In Situ Characterisation of Hydrogels via Dynamic Interface Printing

Advanced Science, EarlyView.
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler, Michael Halwes, David J. Collins   +2 more
wiley   +1 more source

Identifying quality of life domains and facets affected in relapsing polychondritis: a qualitative analysis for the development of a disease-specific health-related quality of life instrument. [PDF]

Orphanet J Rare Dis
Mertz P, Sander O, Faria R, Crisafulli F, Silva-Ribeiro S, Kawka L, Sztejkowski C, Düsing C, Rose T, Lamas A, Vasconcelos C, Fontana G, Semeraro P, Neagu T, Resteu M, Damian L, Pamfil C, Bucsa C, Matthews LJ, Devilliers H, Rednic S, Arnaud L.   +21 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Phase III Study to Confirm Clinical Similarity of MB09, a Denosumab Biosimilar, and Prolia^® in Postmenopausal Women with Osteoporosis (SIMBA Study). [PDF]

Pharmaceutics
Supronik J, Giorgadze E, Blicharski T, Sánchez-Vidaurre S, Pérez-Díaz L, Paravisini A, Millán S.   +6 more
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source