Results 41 to 50 of about 89 (73)

Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau [PDF]

Journal of Neuropathology and Experimental Neurology, 2021
Abstract Abnormal protein accumulation and mislocalization is a general hallmark of Alzheimer disease. Recent data suggest nucleocytoplasmic transport may be compromised by tau in Alzheimer disease. In this context, we have examined the RNA polymerase II subunit RPB1, which is the catalytic subunit that plays a critical role in ...
Matthew Frosch, Bradley Hyman, John Dickson   +2 more
exaly   +3 more sources

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Analysis of fragments of the rpb1 gene sequences of diatoms

Doklady Biochemistry and Biophysics, 2008
I I, Gabaev, E V, Likhoshvai, T A, Shcherbakova, A S, Ostyak   +3 more
exaly   +3 more sources

Cytoplasmic Aggregation of RPB1 Predicts Failure of Neoadjuvant Chemotherapy

2023
Abstract We aimed to investigate the contribution of co-translational protein aggregation to the chemotherapy resistance of tumor cells. Increased co-translational protein aggregation reflects altered translation regulation that may have the potential to buffer transcription under genotoxic stress.
Bence Nagy-Mikó, Orsolya Németh-Szatmári, Réka Faragó-Mészáros, Aliz Csókási, Bence Bognár, Nóra Ördög, Barbara N. Borsos, Hajnalka Majoros, Zsuzsanna Ujfaludi, Orsolya Oláh-Németh, Aliz Nikolényi, Ágnes Dobi, Renáta Kószó, Dóra Sántha, György Lázár, Zsolt Simonka, Attila Paszt, Katalin Ormándi, Tibor Pankotai, Imre M. Boros, Zoltán Villányi, András Vörös   +21 more
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Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II [PDF]

Molecular Cell, 2016
Dynamic interactions between RNA polymerase II and various mRNA-processing and chromatin-modifying enzymes are mediated by the changing phosphorylation pattern on the C-terminal domain (CTD) of polymerase subunit Rpb1 during different stages of transcription.
Scott Ficarro, Un-Beom Kang, Stephen Buratowski   +2 more
exaly   +3 more sources

The C-Terminal Domain of Rpb1 Functions on Other RNA Polymerase II Subunits [PDF]

Molecular Cell, 2013
The C-terminal domain (CTD) of Rpb1, the largest subunit of RNA polymerase II (RNApII), coordinates recruitment of RNA- and chromatin-modifying factors to transcription complexes. It is unclear whether the CTD communicates with the catalytic core region of Rpb1 and thus must be physically connected, or instead can function as an independent domain.
Stephen Buratowski, Hyunsuk Suh
exaly   +3 more sources

Duplication and paralog sorting of RPB2 and RPB1 genes in core eudicots

Molecular Phylogenetics and Evolution, 2007
RPB1 and RPB2, which encode the largest and second largest subunits of RNA polymerase II, respectively, are essential single copy genes in fungi, animals and most plants. Two paralogs of the RPB2 gene have been found in some groups of angioperms [Oxelman, B., Yoshikawa, N., McConaughy, B.L., Luo, J., Denton, A.L., Hall, B.D., 2004.
Jie, Luo, Nori, Yoshikawa, Matthew C, Hodson, Benjamin D, Hall   +3 more
openaire   +2 more sources

Full-length RPB1 is required in two-step shoot regeneration

Biochemical and Biophysical Research Communications, 2018
Regeneration is a complicated progress in plants and animals. Most multicellular organisms can regenerate new tissue when wounded, and plants excel most animals in their ability to regenerate whole new growth module from adult tissues. Regeneration in Arabidopsis includes two steps.
Ying, Li, Die, Hu, Yi, Li, Bo, Yang, Qian, Yu, Lei, Ge   +5 more
openaire   +2 more sources

Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification [PDF]

Nucleic Acids Research, 2015
Transcription by RNA polymerase II (RNAPII) is accompanied by a conserved pattern of histone modifications that plays important roles in regulating gene expression. The establishment of this pattern requires phosphorylation of both Rpb1 (the largest RNAPII subunit) and the elongation factor Spt5 on their respective C-terminal domains (CTDs).
Stewart Shuman, Robert Fisher, Jason Tanny   +2 more
exaly   +3 more sources

Higher-level phylogeny of Foraminifera inferred from the RNA polymerase II (RPB1) gene

European Journal of Protistology, 2007
Macroevolutionary relations among main lineages of Foraminifera have traditionally been inferred from the small subunit ribosomal genes (SSU rDNA). However, important discrepancies in the rates of SSU rDNA evolution between major lineages led to difficulties in accurate interpretation of SSU-based phylogenetic reconstructions.
Jan Pawlowski
exaly   +4 more sources

The distribution of RNA polymerase II largest subunit (RPB1) in the Xenopus germinal vesicle

Journal of Structural Biology, 2002
We describe the localization of the largest subunit of RNA polymerase II (RPB1) in the oocyte nucleus of Xenopus laevis. A single oocyte nucleus contains 18 lampbrush chromosomes, approximately 1500 extrachromosomal nucleoli, 50-100 Cajal bodies (CBs) and hundreds to thousands of B-snurposomes. CBs contain many factors involved in RNA transcription and
Joseph Gall, Jeffry L Corden, Christine Murphy   +2 more
exaly   +3 more sources