Results 1 to 10 of about 511,960 (264)

Chromatin meets RNA polymerase II [PDF]

Genome Biology, 2007
A report on the Cold Spring Harbor Laboratory meeting 'Mechanisms of eukaryotic transcription', Cold Spring Harbor, USA, 2 August-2 September 2007.
Venters, Bryan J, Pugh, B Franklin
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The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

Cell Reports, 2018
Summary: The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that
Cian J. Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano   +16 more
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High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop. [PDF]

PLoS Genetics, 2016
The active sites of multisubunit RNA polymerases have a "trigger loop" (TL) that multitasks in substrate selection, catalysis, and translocation.
Chenxi Qiu, Olivia C Erinne, Jui M Dave, Ping Cui, Huiyan Jin, Nandhini Muthukrishnan, Leung K Tang, Sabareesh Ganesh Babu, Kenny C Lam, Paul J Vandeventer, Ralf Strohner, Jan Van den Brulle, Sing-Hoi Sze, Craig D Kaplan   +13 more
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Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.

PLoS ONE, 2008
The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S.
Jessica L Dermody, Jonathan M Dreyfuss, Judit Villén, Babatunde Ogundipe, Steven P Gygi, Peter J Park, Alfred S Ponticelli, Claire L Moore, Stephen Buratowski, Miriam E Bucheli   +9 more
doaj   +1 more source

PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription

Biomolecules, 2023
The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1 subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription.
Can Balaban, Martin Sztacho, Ludovica Antiga, Ana Miladinović, Masahiko Harata, Pavel Hozák   +5 more
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N4 RNA Polymerase II, a Heterodimeric RNA Polymerase with Homology to the Single-Subunit Family of RNA Polymerases [PDF]

Journal of Bacteriology, 2002
ABSTRACTBacteriophage N4 middle genes are transcribed by a phage-coded, heterodimeric, rifampin-resistant RNA polymerase, N4 RNA polymerase II (N4 RNAPII). Sequencing and transcriptional analysis revealed that the genes encoding the two subunits comprising N4 RNAPII are translated from a common transcript initiating at the N4 early promoter Pe3.
S H, Willis, K M, Kazmierczak, R H, Carter, L B, Rothman-Denes   +3 more
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Association of the Influenza A Virus RNA-Dependent RNA Polymerase with Cellular RNA Polymerase II [PDF]

Journal of Virology, 2005
ABSTRACT Transcription by the influenza virus RNA-dependent RNA polymerase is dependent on cellular RNA processing activities that are known to be associated with cellular RNA polymerase II (Pol II) transcription, namely, capping and splicing.
Engelhardt, O, Smith, M, Fodor, E
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Effect of CFIm25 knockout on RNA polymerase II transcription

BMC Research Notes, 2018
Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is a highly regulated process. Most human genes have multiple poly(A) sites, which define different possible mRNA ends, suggesting the existence of mechanisms that ...
Michael Tellier, Jessica G. Hardy, Chris J. Norbury, Shona Murphy   +3 more
doaj   +1 more source

THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

iScience, 2023
Summary: THOC5, a member of the THO complex, is essential for the 3′processing of some inducible genes, the export of a subset of mRNAs and stem cell survival.
Mareike Polenkowski, Aldrige Bernardus Allister, Sebastian Burbano de Lara, Andrew Pierce, Bethany Geary, Omar El Bounkari, Lutz Wiehlmann, Andrea Hoffmann, Anthony D. Whetton, Teruko Tamura, Doan Duy Hai Tran   +10 more
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Promoter clearance by RNA polymerase II [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes the transition from initiation into transcript elongation. During this intermediate phase of transcription, contact with initiation factors is lost and stable association with the nascent transcript is established.
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