Results 21 to 30 of about 535,527 (262)
A Movie of RNA Polymerase II Transcription [PDF]
Cell, 2012 We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition.
Cheung, A.C.M., Cramer, P.
openaire +5 more sources
High resolution mapping of enhancer-promoter interactions. [PDF]
PLoS ONE, 2015 RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET
Christopher Reeder +5 more
doaj +1 more source
A remodeled RNA polymerase II complex catalyzing viroid RNA-templated transcription.
PLoS Pathogens, 2022 Viroids, a fascinating group of plant pathogens, are subviral agents composed of single-stranded circular noncoding RNAs. It is well-known that nuclear-replicating viroids exploit host DNA-dependent RNA polymerase II (Pol II) activity for transcription ...
Shachinthaka D Dissanayaka Mudiyanselage +5 more
doaj +1 more source
MDC1 maintains active elongation complexes of RNA polymerase II
Cell Reports, 2023 Summary: The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood.
George Pappas +14 more
doaj +1 more source
Structure of the p53/RNA polymerase II assembly
Communications Biology, 2021 Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II ...
Shu-Hao Liou +4 more
doaj +1 more source
Genetic dissection of the RNA polymerase II transcription cycle
eLife, 2022 How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the ...
Shao-Pei Chou +4 more
doaj +1 more source
In vitro Assessment of RNA Polymerase I Activity
Bio-Protocol, 2017 In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs ...
Marzia Govoni
doaj +1 more source
RNA Polymerase II Elongation Control [PDF]
Annual Review of Biochemistry, 2012 Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to
Qiang, Zhou, Tiandao, Li, David H, Price
openaire +2 more sources
CDK9-dependent RNA polymerase II pausing controls transcription initiation
eLife, 2017 Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear.
Saskia Gressel +6 more
doaj +1 more source
RNA Polymerase II: Just Stopping By [PDF]
Cell, 2007 In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate ...
Lorincz, Matthew C., Schübeler, Dirk
openaire +2 more sources