Results 31 to 40 of about 535,527 (262)
Chromatin meets RNA polymerase II [PDF]
Genome Biology, 2007 A report on the Cold Spring Harbor Laboratory meeting 'Mechanisms of eukaryotic transcription', Cold Spring Harbor, USA, 2 August-2 September 2007.
Venters, Bryan J, Pugh, B Franklin
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Chromatin remodeling by Pol II primes efficient Pol III transcription
Nature Communications, 2023 The packaging of the genetic material into chromatin imposes the remodeling of this barrier to allow efficient transcription. RNA polymerase II activity is coupled with several histone modification complexes that enforce remodeling.
Carlo Yague-Sanz +6 more
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Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
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PLoS ONE, 2014 Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit ...
Jitka Holcakova +8 more
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BMC Evolutionary Biology, 2004 Background The primate-specific Alu elements, which originated 65 million years ago, exist in over a million copies in the human genome. These elements have been involved in genome shuffling and various diseases not only through retrotransposition but ...
Brahmachari Samir K +3 more
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Dephosphorylating eukaryotic RNA polymerase II [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2016 The phosphorylation state of the C-terminal domain of RNA polymerase II is required for the temporal and spatial recruitment of various factors that mediate transcription and RNA processing throughout the transcriptional cycle. Therefore, changes in CTD phosphorylation by site-specific kinases/phosphatases are critical for the accurate transmission of ...
Joshua E, Mayfield +2 more
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A bumpy road for RNA polymerase II
Nature Structural & Molecular Biology, 2015 The identification of a second regulatory checkpoint controlling RNA polymerase II elongation near the poly(A) site of protein-coding genes reveals an additional level of complexity in the modulation of eukaryotic transcriptional elongation and termination.
Giono, Luciana Eugenia +1 more
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SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. [PDF]
PLoS ONE, 2011 BACKGROUND: Scaffold attachment factor A (SAF-A) participates in the regulation of gene expression by organizing chromatin into transcriptionally active domains and by interacting directly with RNA polymerase II. METHODOLOGY: Here we use co-localization,
Dzeneta Vizlin-Hodzic +4 more
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Structure of transcribing RNA polymerase II-nucleosome complex
Nature Communications, 2018 Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an ...
Lucas Farnung +2 more
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Effect of CFIm68 knockdown on RNA polymerase II transcription
BMC Research Notes, 2019 Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier +3 more
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