Results 31 to 40 of about 511,960 (264)
PLoS ONE, 2014 Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit ...
Jitka Holcakova +8 more
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Chromatin remodeling by Pol II primes efficient Pol III transcription
Nature Communications, 2023 The packaging of the genetic material into chromatin imposes the remodeling of this barrier to allow efficient transcription. RNA polymerase II activity is coupled with several histone modification complexes that enforce remodeling.
Carlo Yague-Sanz +6 more
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BMC Evolutionary Biology, 2004 Background The primate-specific Alu elements, which originated 65 million years ago, exist in over a million copies in the human genome. These elements have been involved in genome shuffling and various diseases not only through retrotransposition but ...
Brahmachari Samir K +3 more
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Structure of transcribing RNA polymerase II-nucleosome complex
Nature Communications, 2018 Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an ...
Lucas Farnung +2 more
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Effect of CFIm68 knockdown on RNA polymerase II transcription
BMC Research Notes, 2019 Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier +3 more
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SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. [PDF]
PLoS ONE, 2011 BACKGROUND: Scaffold attachment factor A (SAF-A) participates in the regulation of gene expression by organizing chromatin into transcriptionally active domains and by interacting directly with RNA polymerase II. METHODOLOGY: Here we use co-localization,
Dzeneta Vizlin-Hodzic +4 more
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Genome-wide control of RNA polymerase II activity by cohesin.
PLoS Genetics, 2013 Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest ...
Cheri A Schaaf +8 more
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Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase
Scientific Reports, 2017 Lagging strand DNA synthesis by DNA polymerase requires RNA primers produced by DNA primase. The N-terminal primase domain of the gene 4 protein of phage T7 comprises a zinc-binding domain that recognizes a specific DNA sequence and an RNA polymerase ...
Stefan Ilic +7 more
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RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination.
PLoS Genetics, 2020 RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of ...
Jose F Victorino +10 more
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Life, 2022 RNAs not only offer valuable information regarding our bodies but also regulate cellular functions, allowing for their specific manipulations to be extensively explored for many different biological and clinical applications.
Hyesung Jo, Jiyun Beon, Seung Soo Oh
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