Results 51 to 60 of about 811,464 (309)

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress [PDF]

, 2019
FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases.
Caldecott, Keith W, Gomez-Herreros, Fernando, Green, Ryan L, Hafezparast, Majid, Hermann, Andreas, Martinez-Macias, Maria Isabel, Moore, Duncan A Q, Naumann, Marcel, Van Damme, Philip   +8 more
core   +2 more sources

Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase

Scientific Reports, 2017
Lagging strand DNA synthesis by DNA polymerase requires RNA primers produced by DNA primase. The N-terminal primase domain of the gene 4 protein of phage T7 comprises a zinc-binding domain that recognizes a specific DNA sequence and an RNA polymerase ...
Stefan Ilic, Sabine R. Akabayov, Roy Froimovici, Ron Meiry, Dan Vilenchik, Alfredo Hernandez, Haribabu Arthanari, Barak Akabayov   +7 more
doaj   +1 more source

Effect of CFIm68 knockdown on RNA polymerase II transcription

BMC Research Notes, 2019
Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier, Jessica G. Hardy, Chris J. Norbury, Shona Murphy   +3 more
doaj   +1 more source

Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage [PDF]

, 2017
The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells.
Boros, I.M. (Imre M.), Borsos, B.N. (Barbara N.), Gyenis, A. (Ákos), Huliák, I. (Ildikó), Majoros, H. (Hajnalka), Pankotai, T. (Tibor), Pukler, P. (Peter), Ujfaludi, Z. (Zsuzsanna)   +7 more
core   +2 more sources

Chromatin meets RNA polymerase II [PDF]

Genome Biology, 2007
A report on the Cold Spring Harbor Laboratory meeting 'Mechanisms of eukaryotic transcription', Cold Spring Harbor, USA, 2 August-2 September 2007.
Venters, Bryan J, Pugh, B Franklin
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination.

PLoS Genetics, 2020
RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of ...
Jose F Victorino, Melanie J Fox, Whitney R Smith-Kinnaman, Sarah A Peck Justice, Katlyn H Burriss, Asha K Boyd, Megan A Zimmerly, Rachel R Chan, Gerald O Hunter, Yunlong Liu, Amber L Mosley   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

N4 RNA Polymerase II, a Heterodimeric RNA Polymerase with Homology to the Single-Subunit Family of RNA Polymerases [PDF]

Journal of Bacteriology, 2002
ABSTRACTBacteriophage N4 middle genes are transcribed by a phage-coded, heterodimeric, rifampin-resistant RNA polymerase, N4 RNA polymerase II (N4 RNAPII). Sequencing and transcriptional analysis revealed that the genes encoding the two subunits comprising N4 RNAPII are translated from a common transcript initiating at the N4 early promoter Pe3.
S H, Willis, K M, Kazmierczak, R H, Carter, L B, Rothman-Denes   +3 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source