Results 11 to 20 of about 811,464 (309)
Sequential RNA polymerase II activation drives human hematopoiesis [PDF]
Cell ReportsSummary: Promoter-proximal pausing of RNA polymerase II (Pol II) primes genes for rapid activation, yet how Pol II dynamics are temporally organized in adult stem cells to enable fast and flexible responses to environmental cues remain unknown.
Derek H. Janssens +5 more
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DNA topological regulation in RNA polymerase II transcription [PDF]
Cellular & Molecular Biology LettersRNA polymerase II (Pol II) is the main enzyme that synthesizes protein-coding messenger RNA and a subset of nonprotein coding RNA molecules based on the DNA sequences harboring genetic information in eukaryotes.
Heeyoun Bunch
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Widespread epistasis shapes RNA polymerase II active site function and evolution [PDF]
Nature CommunicationsMulti-subunit RNA Polymerases are responsible for transcription in all kingdoms of life. These enzymes rely on dynamic, highly conserved active site domains such as the so-called “trigger loop” to accomplish steps in the transcription cycle. Mutations in
Bingbing Duan +3 more
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Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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High resolution mapping of enhancer-promoter interactions. [PDF]
PLoS ONE, 2015 RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET
Christopher Reeder +5 more
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RNA polymerase II pausing in development: orchestrating transcription
Open Biology, 2022 The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize ...
Abderhman Abuhashem +2 more
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RNA polymerase II at initiation [PDF]
Proceedings of the National Academy of Sciences, 2003 RNA polymerase II (RNAPII) is the enzyme responsible for synthesis of all mRNA in higher cells. As the central component of the eukaryotic transcription machinery, RNAPII is the final target of regulatory pathways that are ultimately responsible for cellular development, differentiation, and metabolic control.
Francisco J, Asturias, John L, Craighead
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Genome-wide mapping of yeast RNA polymerase II termination. [PDF]
PLoS Genetics, 2014 Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation (non-pA) pathway.
Paul Schaughency +2 more
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Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
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A Movie of RNA Polymerase II Transcription [PDF]
Cell, 2012 We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition.
Cheung, A.C.M., Cramer, P.
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