Results 11 to 20 of about 535,527 (262)
Structure of cytoplasmic RNA polymerase II [PDF]
Nature CommunicationsRNA polymerase II (Pol II) must be assembled in the cytoplasm before it enters the nucleus, where it transcribes protein-coding genes. Although transcription by Pol II is intensively studied, how this central multi-subunit enzyme is made and the role of ...
Annamaria Hlavata +5 more
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DNA topological regulation in RNA polymerase II transcription [PDF]
Cellular & Molecular Biology LettersRNA polymerase II (Pol II) is the main enzyme that synthesizes protein-coding messenger RNA and a subset of nonprotein coding RNA molecules based on the DNA sequences harboring genetic information in eukaryotes.
Heeyoun Bunch
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Sequential RNA polymerase II activation drives human hematopoiesis [PDF]
Cell ReportsSummary: Promoter-proximal pausing of RNA polymerase II (Pol II) primes genes for rapid activation, yet how Pol II dynamics are temporally organized in adult stem cells to enable fast and flexible responses to environmental cues remain unknown.
Derek H. Janssens +5 more
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Single-molecule imaging reveals RNA polymerase II dynamics and TAF1-dependent promoter-proximal pause release [PDF]
Nature CommunicationsEarly transcriptional regulation is a major kinetic bottleneck in gene expression, yet the dynamics of RNA polymerase II in living cells remain poorly understood.
Nayem Haque +3 more
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RNA polymerase II pausing in development: orchestrating transcription
Open Biology, 2022 The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize ...
Abderhman Abuhashem +2 more
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Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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RNA polymerase II at initiation [PDF]
Proceedings of the National Academy of Sciences, 2003 RNA polymerase II (RNAPII) is the enzyme responsible for synthesis of all mRNA in higher cells. As the central component of the eukaryotic transcription machinery, RNAPII is the final target of regulatory pathways that are ultimately responsible for cellular development, differentiation, and metabolic control.
Francisco J, Asturias, John L, Craighead
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Genome-wide mapping of yeast RNA polymerase II termination. [PDF]
PLoS Genetics, 2014 Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation (non-pA) pathway.
Paul Schaughency +2 more
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Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
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RNA polymerase II: the elephant in the room. [PDF]
Trends GenetHow genes respond to external signals is poorly understood, with transcription factors and histones proposed as mediators of signals to RNA polymerase II (Pol II). However, recent work shows that Pol II is the direct target of more than 100 protein kinases, a previously underappreciated mechanism for generating epigenetic complexity.
Henikoff S, Hahn S.
europepmc +3 more sources