Results 211 to 220 of about 208,874 (328)

Drusen in patient-derived hiPSC-RPE models of macular dystrophies

Proceedings of the National Academy of Sciences of the United States of America, 2017
C. Galloway, Sonal Dalvi, Sandy S. C. Hung, Leslie A. MacDonald, L. Latchney, Raymond C. B. Wong, R. Guymer, D. Mackey, David S. Williams, Mina M. Chung, D. Gamm, A. Pébay, A. Hewitt, Ruchira Singh   +13 more
semanticscholar   +1 more source

Jumping on the moon as a potential exercise countermeasure

Experimental Physiology, EarlyView.
Abstract The Moon's gravitational field strength (17% Earth's gravity) may facilitate the use of bodyweight jumping as an exercise countermeasure against musculoskeletal and cardiovascular deconditioning in reduced gravity settings. The present study characterised the acute physiological and kinetic responses to bodyweight jumping in simulated Lunar ...
Patrick Swain, Filipa Santos, Luke Hughes, Dan Gordon, Nick Caplan   +4 more
wiley   +1 more source

CRX is an intrinsic suppressor of epithelial‒mesenchymal transition in retinal pigment epithelial cells: a promising therapeutic avenue for subretinal fibrosis. [PDF]

Cell Death Dis
Li D, Ou Q, Gao F, Wang X, Zhu L, Zhou Y, Xu JY, Jin C, Wang J, Zhang J, Li J, Bi Y, Lu L, Xu GT, Tian H.   +14 more
europepmc   +1 more source

Assessing the exercise‐related kinetics of circulating cell‐free DNA, circulating tumour DNA, DNase I activity and cytokines in patients with solid tumours: A pilot study

Experimental Physiology, EarlyView.
Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger, Alexandra Brahmer, Tobias Ehlert, Suzan Botzenhardt, Alfonso De Falco, Birgit Enders, Patricia S. Hähnel, Achim Heintz, Carl C. Schimanski, Thomas Kindler, Perikles Simon   +10 more
wiley   +1 more source

One minute of light‐intensity stair‐stepping decreases postprandial glycaemia in the evening in non‐diabetic adults: A randomized controlled trial

Experimental Physiology, EarlyView.
Abstract Prior studies have investigated the efficacy of a single 1 min bout of stair‐stepping on reducing postprandial blood glucose (BG) in the morning, but none have investigated this effect in the evening when glycaemic responses are larger due to circadian regulation and β‐cell responsiveness. This work investigated the efficacy of a 1 min bout of
Austin Morales, William Wong, Jeff Moore, Jochen Kressler   +3 more
wiley   +1 more source

Prognostic Ability of Automated RPE Sinuosity for Late AMD Supersedes Qualitative Outer Retinal Band Assessment. [PDF]

Invest Ophthalmol Vis Sci
Cheung R, Trinh M, Duong A, Chen S, Ng D, Schiller G, Hodge C, Nivison-Smith L.   +7 more
europepmc   +1 more source

Isolation, culture and characterization of primary mouse RPE cells

Nature Protocols, 2016
Rosario Fernandez‐Godino, D. Garland, E. Pierce   +2 more
semanticscholar   +1 more source

Trimethylamine N‐oxide is elevated in postmenopausal women relative to age‐matched men and premenopausal women among individuals with obesity

Experimental Physiology, EarlyView.
Abstract Trimethylamine N‐oxide (TMAO) is linked to arterial stiffness and atherosclerosis. Cardiovascular disease (CVD) risk increases following menopause in women. Whether menopause influences plasma TMAO metabolism to mediate CVD risk is unknown.
Daniel J. Battillo, Steven K. Malin
wiley   +1 more source

Commuting by bicycle (vs. by car) is associated with improved aerobic power, microvascular function and diminished CO2 output in the atmosphere

Experimental Physiology, EarlyView.
Abstract The study investigated whether bicycle compared with car commuting, over relatively small distances, has positive effects on physiological variables, cardiometabolic fitness and CO2 output in the atmosphere. Bike Commuters (11 M, 15 F; age [median value (interquartile range)] 51.5 (38.3–56.8) years; body mass index [BMI] 22.8 (21.0–24.1) kg m ...
Caterina Ursella, Giovanni Baldassarre, Lucrezia Zuccarelli, Federica Caponnetto, Francesco Curcio, Mattia D'Alleva, Maria De Martino, Elisabetta Fontanini, Andrea Palomba, Antonio Paolo Beltrami, Federico Formenti, Bruno Grassi   +11 more
wiley   +1 more source

Acute exercise‐induced improvements in cognition: Role of cerebral blood flow and metabolism

Experimental Physiology, EarlyView.
Abstract Physical activity is widely recognized for its ability to promote brain health, with acute exercise transiently enhancing cognition and long‐term training attenuating cognitive decline. However, the mechanisms underlying these benefits remain incompletely understood.
Takeshi Hashimoto, Shigehiko Ogoh
wiley   +1 more source