Results 191 to 200 of about 77,663 (265)

Targeting ferroptosis in ocular diseases: mechanisms, clinical implications, and therapeutic horizons. [PDF]

Int J Ophthalmol
Zhang NY, Kong HQ, Liao YQ, Pan YJ, Sun W, Xi L, Yu HH, Shi YH.   +7 more
europepmc   +1 more source

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller, Romy Busch, Giuseppe Faudone, Felia C. Haffelder, Jan Vietor, Arthur Kardanov, Úrsula López‐García, Arne Hackspacher, Georg Höfner, Vasily Morozov, Susanne F. Koch, Julian A. Marschner, Daniel Merk   +12 more
wiley   +1 more source

Longitudinal Prediction of Retinal Sensitivity Based on Disease Progression Quantified From Optical Coherence Tomography in Geographic Atrophy. [PDF]

Invest Ophthalmol Vis Sci
Birner K, Mai J, Boryshchuk D, Frommlet F, Schwartz R, Schürer-Waldheim S, Leingang O, Dieter-Vogl W, Schmidt-Erfurth U.   +8 more
europepmc   +1 more source

MIGC: Pseudotime differentially expressed genes detection with mutual information

Quantitative Biology, Volume 14, Issue 4, December 2026.
Abstract Trajectory analysis of single‐cell RNA sequencing (scRNA‐seq) data provides insights into cell differentiation and the underlying mechanisms at the gene level. Although various pseudotime inference methods have been proposed, the detection of pseudotime differentially expressed genes (DEGs) mainly relies on generalized additive model fitting ...
Jiachen Li, Ye Yuan
wiley   +1 more source

Choriocapillaris Dysfunction in Retinal Diseases: Multimodal Imaging Biomarkers, Pathophysiological Insights, and Emerging Clinical Applications. [PDF]

Biomedicines
Menna F, Meduri A, De Luca L, Baldascino A, Lupo S, Vingolo EM.   +5 more
europepmc   +1 more source

Mass Spectrometry for Semiquantitative Analysis of Thermal Decomposition: A Methodological Case Study on the Pyrolysis of a (CH3)SiO1.5 Hybrid Gel

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale The thermal decomposition of (CH3)SiO1.5 gels has been systematically investigated by TG‐MS, revealing a complex temperature‐dependent evolution of gaseous species. This work demonstrates that the TG‐MS analysis, coupled with rigorous data processing, allows to set up an insightful methodology to evolve from a qualitative monitoring ...
Renzo Campostrini, Graziano Guella, Peter Kroll, Maurizio Grigiante   +3 more
wiley   +1 more source

Clinical Classification of Radiation Maculopathy as a Predictor of Functional Response to Intravitreal Dexamethasone Implant. [PDF]

J Clin Med
Parrozzani R, Gava S, Molin C, Midena E, Midena G.   +4 more
europepmc   +1 more source

Whole genome duplication through mitotic slippage causes nuclear instability. [PDF]

EMBO J
Gemble S, Budzyk M, Simon A, Lambuta R, Nanni L, Weiss N, Forest A, Miroshnikova Y, Scotto Di Carlo F, Marthiens V, Verdel C, Fang J, Desdouets C, Wickström SA, Ciriello G, Oricchio E, Almouzni G, Basto R.   +17 more
europepmc   +1 more source

Alpha-Asarone Ameliorates Dry Age-Related Macular Degeneration by Modulating the P2X7/NLRP3 Inflammasome Axis. [PDF]

Invest Ophthalmol Vis Sci
Wang X, Bi Y, Liu Y, Nie Y, Ding J, Yu L, Mao S.   +6 more
europepmc   +1 more source