Results 121 to 130 of about 11,678 (224)
ABSTRACT Purpose Cerebrovascular reactivity (CVR) provides an important index of vascular health and is conventionally quantified using a hypercapnic gas or breath‐hold challenge in conjunction with blood‐oxygen‐level‐dependent functional magnetic resonance imaging (BOLD‐fMRI).
Abdoljalil Addeh +9 more
wiley +1 more source
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer +4 more
wiley +1 more source
This project outlines the Regenerative Restoration Framework (RRF), an open-source, actionable plan designed to restore ecosystems, empower communities, and provide sustainable solutions to global environmental challenges.
ERI-IRFOS (Earth Refocus Institute - Interdisciplinary Research Facility for Open Sciences)
core +2 more sources
Intestinal elt-2 RNAi induces prominent phenotypes in rrf-1 mutants.
The indicated C. elegans strains were raised on bacteria expressing elt-2 dsRNA and imaged by DIC microscopy on day 3 of adulthood. The rde-1 strain and the rde-1 strain expressing RDE-1 in the hypodermis (lin-26p::rde-1) were unaffected by RNAi, whereas
Malene Hansen (10367) +1 more
core +1 more source
ABSTRACT Motivation Dental enamel possesses a unique anisotropic, heterogeneous hierarchical structure which enables a combination of high hardness and remarkable durability compared to other natural and synthetic biomaterials. Nevertheless, it undergoes mechanical degradation through fracture from concentrated overloads and/or progressive wear, both ...
Estíbaliz Sánchez‐González +5 more
wiley +1 more source
Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum
Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz +23 more
wiley +1 more source
The Path-Breaking Potential of the Recovery and Resilience Facility: An Analysis of the Shifts in EU’s Distributional Policy Mode with Insights from Romania’s Experience [PDF]
In May 2020, the Recovery and Resilience Facility (RRF) was presented as a unique instrument, due to its ambition, form, and the mechanisms with which it is equipped.
Nicolae Toderaș
doaj
ABSTRACT In response to the COVID‐19 crisis, the European Union introduced NextGenerationEU, its largest stimulus package to date. We focus on Italy, the program's largest beneficiary, and analyse the territorial distribution of funds. Although centrally coordinated, most expenditures were awarded through calls and implemented by local governments ...
Francesco Scotti +2 more
wiley +1 more source

