Results 51 to 60 of about 489 (157)

MINRbase: a comprehensive database of nuclear- and mitochondrial-ribosomal-RNA-derived fragments (rRFs)

Nucleic Acids Research, 2023
Abstract We describe the Mitochondrial and Nuclear rRNA fragment database (MINRbase), a knowledge repository aimed at facilitating the study of ribosomal RNA-derived fragments (rRFs). MINRbase provides interactive access to the profiles of 130 238 expressed rRFs arising from the four human nuclear rRNAs (18S, 5.8S, 28S, 5S), two ...
Venetia Pliatsika, Tess Cherlin, Phillipe Loher, Panagiotis Vlantis, Parth Nagarkar, Stepan Nersisyan, Isidore Rigoutsos   +6 more
openaire   +2 more sources

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Cigarette Smoking and Chronic Kidney Disease in African Americans in the Jackson Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundControversy exists regarding the association of cigarette smoking and renal dysfunction, particularly among African Americans, who are disproportionately affected by chronic kidney disease; therefore, we evaluated the relationship between ...
Michael E. Hall, Wei Wang, Victoria Okhomina, Mohit Agarwal, John E. Hall, Albert W. Dreisbach, Luis A. Juncos, Michael D. Winniford, Thomas J. Payne, Rose M. Robertson, Aruni Bhatnagar, Bessie A. Young   +11 more
doaj   +1 more source

Effect of rice-rice-rape rotation on physicochemical property and bacterial community of rhizosphere soil

Oil Crop Science, 2020
Through collecting rhizosphere soil sample from a 30-year long-term fixed location test site that use “rice-rice-rape” crop rotation (RRR) and “rice-rice-fallow” continuous cropping systems (RRF), this paper investigated effects of long-term crop ...
Licheng Zhang, Juan Li, Mingqing Zhang
doaj   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

Preimplantation genetic testing for aneuploidy optimizes reproductive outcomes in recurrent reproductive failure: a systematic review

Frontiers in Medicine
IntroductionRecurrent reproductive failure (RRF) is a common pregnancy complication, imposing great physical, emotional and financial burden for the suffered couples.
Youwen Mei, Yonghong Lin, Ying Chen, Jiafeng Zheng, Xue Ke, Xuefei Liang, Fang Wang   +6 more
doaj   +1 more source

Structure and Binding Mode of a Ribosome Recycling Factor (RRF) from Mesophilic Bacterium [PDF]

Journal of Biological Chemistry, 2003
X-ray and NMR analyses on ribosome recycling factors (RRFs) from thermophilic bacteria showed that they display a tRNA-like L-shaped conformation consisting of two domains. Since then, it has been accepted that domain I, consisting of a three-helix bundle, corresponds to the anticodon arm of tRNA and domain II and a beta/alpha/beta sandwich structure ...
Hiroaki, Nakano, Takuya, Yoshida, Susumu, Uchiyama, Masako, Kawachi, Hitomi, Matsuo, Takayuki, Kato, Atsushi, Ohshima, Yoshiharu, Yamaichi, Takeshi, Honda, Hiroaki, Kato, Yuriko, Yamagata, Tadayasu, Ohkubo, Yuji, Kobayashi   +12 more
openaire   +2 more sources

Carbon Performance, Climate Governance, and Equity Risk

International Journal of Finance &Economics, EarlyView.
ABSTRACT This paper examines the relationship between carbon performance, climate governance, and equity risk. Using a sample of companies listed in the S&P500 index for the period 2009–2023, our results show that better carbon performance reduces equity risk, indicating that proactive carbon management reduces uncertainty and is beneficial to firms ...
Malafronte Irma, Pereira John, Rakeeb Fathima Roshan   +2 more
wiley   +1 more source

Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation

Renal Failure
Background The potential impact of elevated intra-abdominal pressure (IAP) on residual renal function (RRF) has not been determined. The objective of this study was to investigate the relationship between IAP and the rate of RRF decline in newly ...
Jingjing Zhang, Lei Song, Zhongwei Ma, Lina Sun, Xiaoqing Wang, Duanyan Liu, Feng Huang, Yulin Man   +7 more
doaj   +1 more source