Results 91 to 100 of about 11,678 (224)

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G). [PDF]

open access: yes, 2008
Ribosome recycling factor (RRF), elongation factor G (EF-G) and GTP split 70S ribosomes into subunits. Here, we demonstrated that the splitting was transient and the exhaustion of GTP resulted in re-association of the split subunits into 70S ribosomes ...
Hirokawa, Go   +3 more
core   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam   +3 more
wiley   +1 more source

Environmental Morphological Divergence and Its Integration With Collective Behavior in Cooperative Pseudoscorpions

open access: yesEthology, EarlyView.
In the social pseudoscorpion Paratemnoides nidificator, populations across contrasting urban and peri‐urban environments exhibit marked morphological divergence and consistent sexual dimorphism. Crucially, relative development of the prey‐capture pedipalp apparatus (rather than absolute body size) is positively integrated with proactive collective ...
Renan Filgueiras Ribeiro   +1 more
wiley   +1 more source

Is half the world's population really below 'replacement-rate'?

open access: yesPLoS ONE, 2019
A perennial activity of demographers is to estimate the percentage of the world's population which is above or below the 'replacement rate of fertility' [RRF].
Stuart Gietel-Basten, Sergei Scherbov
doaj   +1 more source

Metabolic and volume status evaluation of hemodialysis patients with and without residual renal function in the long interdialytic interval

open access: yesBrazilian Journal of Nephrology, 2019
Introduction: It is unclear whether residual renal function (RRF) in dialysis patients can attenuate the metabolic impact of the long 68-hour interdialytic interval, in which water, acid, and electrolyte accumulation occurs. Objective: to evaluate serum
Lenina Ludimila Sampaio de Almeida   +5 more
doaj   +1 more source

Perceived discrepancies in neurosonology training and certification across Europe: a RRFS/EAN survey [PDF]

open access: yesFrontiers in Neurology
IntroductionNeurosonology is a vital paraclinical investigation in modern neurology. However, access to education and certification in neurosonology for neurology residents and young specialists in Europe is challenging, and comprehensive data regarding this topic are scarce.
Vlad Tiu   +14 more
openaire   +3 more sources

Logistics Management Information System (LMIS) for Health Commodities at Public Health Facilities in Amhara National Regional State of Ethiopia: A Data Quality Evaluation Survey

open access: yesJournal of Multidisciplinary Healthcare
Zelalem Tilahun Mekonen,1 Denny J Cho,2 Teferi Gedif Fenta1 1Department of Pharmaceutics and Social Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia; 2Logistics Department, Kyrgyz State Technical University, Bishkek, KyrgyzstanCorrespondence ...
Mekonen ZT, Cho DJ, Fenta TG
doaj  

Reimagining State Aid: Guiding Law and Policy Reform in a Changing World

open access: yesEuropean Law Journal, EarlyView.
ABSTRACT EU state aid law has shifted fundamentally from an originally purely repressive tool to a proactive steering mechanism for critical EU goals today. This paper argues that the current legal framework in Article 107 TFEU is gravely misaligned with this new function.
Thomas Jaeger
wiley   +1 more source

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