Results 81 to 90 of about 489 (157)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten

Frontiers in Immunology
IntroductionThe prevalence of gluten-related disorders, mainly celiac disease (CD) and non-celiac gluten sensitivity (NCGS), varies between 0.6% and 13% in the general population.
Eduardo de la Fuente-Munoz, Eduardo de la Fuente-Munoz, Miguel Fernández-Arquero, Miguel Fernández-Arquero, Nabil Subhi-Issa, Nabil Subhi-Issa, Kissy Guevara-Hoyer, Kissy Guevara-Hoyer, Kissy Guevara-Hoyer, Lydia Pilar Suárez, Raquel Gil Laborda, Marina Sánchez, Juliana Ochoa-Grullón, Juliana Ochoa-Grullón, María Guzmán-Fulgencio, María Guzmán-Fulgencio, Ángela Villegas, Ángela Villegas, María Dolores Mansilla, María Dolores Mansilla, Noelia Pérez, Ricardo Savirón Cornudella, Teresa Gastañaga-Holguera, Marta Calvo Urrutia, Ignacio Cristóbal García, Silvia Sánchez-Ramón, Silvia Sánchez-Ramón   +26 more
doaj   +1 more source

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész, Tamás Mészáros, Bálint A. Barta, Réka Facsko, Anna Szilasi, Tamás Bakos, Gergely T. Kozma, Attila B. Dobos, Béla Merkely, Tamás Radovits, János Szebeni   +13 more
wiley   +1 more source

Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum

Clinical Genetics, EarlyView.
Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz, Simone Carbonera, Mónica Mora‐Gómez, Natalia Gallego‐Zazo, Inmaculada Guillén, Elena Padilla, Gaia Visani, Alessia Asaro, Valeria Vásquez‐Amell, Mario Cazalla, Manuel Rodríguez‐Canó, Cristina Silván, Pedro Arias, Juan Andrés Jiménez‐Estrada, Tomás Valle, Alejandro Cruz‐Utrilla, Pilar Escribano‐Subías, Nuria Ochoa Parra, María Jesús del Cerro Marín, Julián Nevado, Spanish PAH Consortium, Pablo Lapunzina, Fabio Sirchia, Jair Tenorio‐Castano   +23 more
wiley   +1 more source

腹膜透析患者残余肾功能的影响因素及保护策略

Zhongguo shiyan zhenduanxue, 2014
腹膜透析（peritoneal dialysis,PD）是治疗终末期肾病（end stage renal diseases,ESRD）的替代疗法之一。残余肾功能（residual renal function,RRF）是指肾组织受损后尚健存的清除及内分泌功能。有RRF的PD患者其残肾清除率明显高于无RRF患者,多项研究已做了相关报道。保护RRF能够有效的提高透析患者的生活质量。然而 ...
沈立婷, 崔燕, 崔明姬
doaj  

The Political Legitimacy of Multilevel Crisis Governance: The EU's Recovery and Resilience Facility

JCMS: Journal of Common Market Studies, EarlyView.
Abstract European‐wide crises have required extraordinary responses from the EU and its member states that affected its governance and legal framework as well as its legitimacy. The recent COVID‐19 pandemic spread across borders and involved multiple levels of government to mitigate its socio‐economic impact and facilitate a swift recovery.
Marius Guderjan, Mario Kölling
wiley   +1 more source

Experimental Assessment of Measurement Uncertainty for a Green-Wavelength LiDAR System [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Green-wavelength LiDAR systems enable high-resolution 3D sensing in underwater environments, but the geometric evaluation of measurements acquired across the waterline remains challenging.
Y. Lan, J. Wang, J. Yang, M. Kolling, A. Dorndorf, C. Werner, A. Reiterer, A. Reiterer, J.-A. Paffenholz   +8 more
doaj   +1 more source

SEUPD@CLEF: Team HIBALL on Incremental Information Retrieval System with RRF and BERT. [PDF]

, 2023
This report showcases the work of the HIBALL team from the University of Padua on Task 1 LongEval-Retrieval of CLEF 2023 [1] [2]. Our goal was to create a general-purpose information retrieval system, using the CLEF document corpus and judgments as our reference.
Ceccato A., Fabbian L., Huang B. -W., Khan I. U., Singh H., Ferro N.   +5 more
openaire   +1 more source

The Adaptive Stability of the European Union's Long‐Term Budget

JCMS: Journal of Common Market Studies, EarlyView.
Abstract This article examines the adaptive stability of the European Union's long‐term budget from the Delors I package of 1988–1992 to the Multiannual Financial Framework of 2014–2020, focusing on the Common Agricultural Policy (CAP) and Cohesion Policy.
David Moloney, Mads Dagnis Jensen
wiley   +1 more source