Results 101 to 110 of about 9,963 (233)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Journal of Multidisciplinary HealthcareZelalem Tilahun Mekonen,1 Denny J Cho,2 Teferi Gedif Fenta1 1Department of Pharmaceutics and Social Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia; 2Logistics Department, Kyrgyz State Technical University, Bishkek, KyrgyzstanCorrespondence ...
Mekonen ZT, Cho DJ, Fenta TG
doaj
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam +3 more
wiley +1 more source
The FEBS Journal, EarlyView.Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy +7 more
wiley +1 more source
Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten
Frontiers in ImmunologyIntroductionThe prevalence of gluten-related disorders, mainly celiac disease (CD) and non-celiac gluten sensitivity (NCGS), varies between 0.6% and 13% in the general population.
Eduardo de la Fuente-Munoz +26 more
doaj +1 more source
The Political Legitimacy of Multilevel Crisis Governance: The EU's Recovery and Resilience Facility
JCMS: Journal of Common Market Studies, EarlyView.Abstract European‐wide crises have required extraordinary responses from the EU and its member states that affected its governance and legal framework as well as its legitimacy. The recent COVID‐19 pandemic spread across borders and involved multiple levels of government to mitigate its socio‐economic impact and facilitate a swift recovery.
Marius Guderjan, Mario Kölling
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2014 腹膜透析（peritoneal dialysis,PD）是治疗终末期肾病（end stage renal diseases,ESRD）的替代疗法之一。残余肾功能（residual renal function,RRF）是指肾组织受损后尚健存的清除及内分泌功能。有RRF的PD患者其残肾清除率明显高于无RRF患者,多项研究已做了相关报道。保护RRF能够有效的提高透析患者的生活质量。然而 ...
沈立婷, 崔燕, 崔明姬
doaj
The Adaptive Stability of the European Union's Long‐Term Budget
JCMS: Journal of Common Market Studies, EarlyView.Abstract This article examines the adaptive stability of the European Union's long‐term budget from the Delors I package of 1988–1992 to the Multiannual Financial Framework of 2014–2020, focusing on the Common Agricultural Policy (CAP) and Cohesion Policy.
David Moloney, Mads Dagnis Jensen
wiley +1 more source
, 2018 Markers of oxidative stress (A), inflammation (B) and endothelial dysfunction (C) were significantly decreased in addition to a significant increase in anti-oxidant capacity on HDF compared to HD.
Helen Aitkenhead (5409914) +9 more
core +1 more source
The Return of Industrial Policy in the EU: A Chance for Central and Eastern Europe?
JCMS: Journal of Common Market Studies, EarlyView.Abstract This contribution explores the Visegrad four's (V4) responses to the revival of industrial policy in the European Union (EU). To a region so highly industrialised, and so dependent on foreign firms, this revival brings mixed blessings. Industrial policy focused on ‘European champions’ is driving investment towards core regions and firms ...
Vera Šćepanović, Imre G. Szabó
wiley +1 more source