Results 31 to 40 of about 9,963 (233)

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening. [PDF]

Chembiochem
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Csorba N, Ábrányi-Balogh P, Orgován Z, Szalai TV, Ferenczy GG, Kollár L, Péczka N, Imre T, Simon J, Szabó P, Schlosser G, Hrast M, Gobec S, Ivanova V, Galdeano C, Kopranovic A, Neumann M, Meyer-Almes FJ, Keserű GM.   +18 more
europepmc   +2 more sources

IMPACT OF RESIDUAL RENAL FUNCTION ON CHANGES OF BODY COMPOSITION IN DIABETIC CAPD PATIENTS

Kidney Research and Clinical Practice, 2012
Purpose: Preservation of residual renal function (RRF) in peritoneal dialysis patient is essential to improve clinical outcomes. Therefore, we conducted a prospective observational study to investigate the effect of low RRF in early period on body ...
Kyu-Hyang Cho, Jun-Young Do, Soek-Hui Kang, Jong-Won Park, Kyung-Woo Yoon   +4 more
doaj   +1 more source

The Impact of Fluid Overload and Variation on Residual Renal Function in Peritoneal Dialysis Patient. [PDF]

PLoS ONE, 2016
BACKGROUND:The effect of fluid overload and variation on residual renal function (RRF) in peritoneal dialysis (PD) patients is controversial. METHODS:Retrospective cohort study was designed.
Na Tian, Qunying Guo, Qian Zhou, Peiyi Cao, Lingyao Hong, Menghua Chen, Xiao Yang, Xueqing Yu   +7 more
doaj   +1 more source

Impacts of Protein from High-Protein Rice on Gelatinization and Retrogradation Properties in High- and Low-Amylose Reconstituted Rice Flour

Agronomy, 2022
High-protein rice is nutritional, but its taste attributes are inferior to low-protein rice. Many documents correlate its taste attributes with its gelatinization and retrogradation properties.
Yitong Zhao, Xianggui Dai, Enerand Mackon, Yafei Ma, Piqing Liu   +4 more
doaj   +1 more source

Cerebral microbleeds in traumatic brain injury: their impact on white matter integrity assessed by diffusion MRI

Frontiers in Neurology
IntroductionTraumatic Brain Injury (TBI) often leads to lasting cognitive and functional deficits, with Traumatic Axonal Injury (TAI) being a significant prognostic factor.
Dávid Bognár, Dávid Bognár, Dávid Bognár, Zalán Petneházy, Zalán Petneházy, Zalán Petneházy, Péter Laár, Péter Laár, Tamás Dóczi, Tamás Dóczi, Tamás Dóczi, Attila Schwarcz, Attila Schwarcz, Attila Schwarcz, Bálint S. Környei, Bálint S. Környei, Bálint S. Környei, Arnold Tóth, Arnold Tóth, Arnold Tóth   +19 more
doaj   +1 more source

Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function

Renal Failure, 2019
Introduction: Increased serum alkaline phosphatase (ALP) is predictive of a higher mortality in patients with end-stage renal disease. However, it remains unknown whether residual renal function (RRF) influences the outcome-association of serum ALP among
Xiaojiang Zhan, Yuting Yang, Yanbing Chen, Xin Wei, Jun Xiao, Li Zhang, Caixia Yan, Panlin Qiu, Siyi Liu, Qinglan Hu, Qinkai Chen, Yu Wang   +11 more
doaj   +1 more source

Rapid Fragment Screening by 19F Steady‐State Free Precession NMR

Angewandte Chemie, EarlyView.
19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša, Sintija Ozola, Kostiantyn P. Melnykov, Yaroslav I. Filatov, Serhiy V. Ryabukhin, Raitis Bobrovs, Dmytro M. Volochnyuk, Kristaps Jaudzems, Rihards Aleksis   +8 more
wiley   +2 more sources

Nomogram model based on clinical factors and autonomic nervous system activity for predicting residual renal function decline in patients undergoing peritoneal dialysis

Frontiers in Neuroscience
BackgroundSeveral heart rate variability (HRV) parameters were reported to be associated with residual renal function (RRF) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
Jing Wang, Zhenye Chen, Yaoyu Huang, Yujun Qian, Hongqing Cui, Li Zhang, Yike Zhang, Ningning Wang, Hongwu Chen, Haibin Ren, Huijuan Mao   +10 more
doaj   +1 more source

The Effect of Preserved Residual Renal Function on Left Ventricular Structure in Non-Anuric Peritoneal Dialysis Patients

Kidney & Blood Pressure Research, 2015
Background/Aims: Residual renal function (RRF) has been shown to influence survival of peritoneal dialysis (PD) patients. This study examined the relations between RRF and left ventricular hypertrophy (LVH) before switching on dialysis treatment and ...
Damir Rebić, Mirjana Sabljar Matovinović, Senija Rašić, Petar Kes, Aida Hamzić-Mehmedbašić   +4 more
doaj   +1 more source

Strong earthquake recurrence interval in the southern segment of the Red River Fault, southwestern China

Frontiers in Earth Science, 2023
Along the southeastern margin of the Tibetan Plateau, an important boundary fault, known as the Red River Fault (RRF), formed during the extrusion of mantle and lower crustal materials beneath the Tibetan Plateau.
Qingyun Zhou, Qingyun Zhou, Xi Li, Yuqiao Chang, Jiang Yu, Weidong Luo, Xianfu Bai   +6 more
doaj   +1 more source