Results 131 to 140 of about 56,656 (285)

Revitalizing reproductive health: innovations and future frontiers in restorative medicine

Therapeutic Advances in Reproductive Health
Background: Infertility affects around 17.5% of reproductive-aged individuals worldwide, posing significant personal and public health challenges.
Francesco Maria Bulletti, Evaldo Giacomucci, Maurizio Guido, Antonio Palagiano, Maria Elisabetta Coccia, Carlo Bulletti   +5 more
doaj   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, EarlyView.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

A unified formulation for home healthcare routing and scheduling problems

International Transactions in Operational Research, EarlyView.
Abstract Home Healthcare is an essential component of healthcare systems, where caregivers visit patients' homes to deliver services. While presenting advantages with respect to institutional care, such as being cost‐effective and alleviating family burdens, it presents challenges in scheduling and routing caregivers efficiently.
Sara Ceschia, Francesca Da Ros, Luca Di Gaspero, Simona Mancini, Vittorio Maniezzo, Roberto Montemanni, Roberto Maria Rosati, Andrea Schaerf   +7 more
wiley   +1 more source

Exact and metaheuristic approaches to minimizing makespan in parallel machine scheduling with conflicting jobs

International Transactions in Operational Research, EarlyView.
Abstract We address the scheduling conflicting jobs on parallel identical machines problem with makespan minimization, a classical and computationally challenging variant of parallel machine scheduling. We develop and evaluate three distinct solution methodologies: a novel constraint programming (CP) formulation, and two metaheuristics: a multi ...
Roberto Maria Rosati, Dinh Quy Ta, Minh Hoàng Hà, Andrea Schaerf   +3 more
wiley   +1 more source

Parent‐led CBT delivered via online and telephone support alongside usual school practice versus usual school practice only for young children identified as at risk for anxiety disorders through screening in schools: a cluster randomised controlled trial

Journal of Child Psychology and Psychiatry, EarlyView.
Background Providing accessible CBT for young children identified as at risk for anxiety disorders through screening in schools could reduce later problems. This study aimed to evaluate the effectiveness of parent‐led CBT delivered via online and telephone call support alongside usual school provision, compared to usual school provision only for young ...
Tessa Reardon, Obioha C. Ukoumunne, Helen Dodd, Gemma Halliday, Claire Hill, Bec Jasper, Benjamin Jones, Peter J. Lawrence, Fran Morgan, Anna Placzek, Ronald M. Rapee, Mara Violato, Shuye Yu, MYCATS Team, Cathy Creswell, Emily Davey, Jeni Fisk, Iheoma Green, Laura Hankey, Elizabeth Hindhaugh, Chloe Hooper, Lindsey Martineau, Amy McCall, Natascha Niekamp, Natasha Pall, Samantha Pearcey, Ruth Potts, Abigail Thomson, Tamatha Weisser, Joshua Wright, Siyu Zhou   +30 more
wiley   +1 more source

RRM modelling & RNA-RRM docking software

A software package that will enable the modelling of RRMs from sequence, and the ability to dock RNAs to these models and to experimentally determined structures.
openaire   +1 more source

Prospects of multipurpose biomonitoring for fisheries assessment based on environmental nucleic acids

Journal of Fish Biology, EarlyView.
Abstract Methods using environmental nucleic acids have become highly effective for monitoring aquatic biodiversity, with an array of suitable use cases, including metrics for fisheries assessment. Traditional methods for assessing fish populations often rely on invasive techniques with limited spatial and temporal coverage.
Ana Ramón‐Laca, Krista M. Nichols, Kim M. Parsons, Ramón Gallego, David R. Vieites, Ignacio Doadrio, Ana Riesgo   +6 more
wiley   +1 more source

Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications

Journal of Integrative Plant Biology, EarlyView.
Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu, Maohong Cai, Rongrong Zhai, Jing Ye, Guofu Zhu, Faming Yu, Shenghai Ye, Xiaoming Zhang   +7 more
wiley   +1 more source

Sleep and cardiac autonomic modulation in older adults: Insights from an at‐home study with auditory deep sleep stimulation

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The autonomic nervous system regulates cardiovascular activity during sleep, likely impacting cardiovascular health. Aging, a primary cardiovascular risk factor, is associated with cardiac autonomic disbalance and diminished sleep slow waves. Therefore, slow waves may be linked to aging, autonomic activity and cardiovascular health. However, it
Stephanie Huwiler, M. Laura Ferster, Luzius Brogli, Reto Huber, Walter Karlen, Caroline Lustenberger   +5 more
wiley   +1 more source