Results 111 to 120 of about 675,402 (336)

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Complete genome sequence of Meiothermus silvanus type strain (VI-R2). [PDF]

, 2010
Meiothermus silvanus (Tenreiro et al. 1995) Nobre et al. 1996 belongs to a thermophilic genus whose members share relatively low degrees of 16S rRNA gene sequence similarity.
Bristow, James, Chang, Yun-Juan, Chen, Amy, Cheng, Jan-Fang, Copeland, Alex, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Han, Cliff, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Land, Miriam, Lapidus, Alla, Liolios, Konstantinos, Lowry, Stephen, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Mikhailova, Natalia, Nolan, Matt, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Sikorski, Johannes, Tice, Hope, Tindall, Brian J, Woyke, Tanja   +32 more
core   +1 more source

The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots

Advanced Science, EarlyView.
DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya, Nikolai Davey, Pranjal Srivastava, Andrew Bender, Léo Pio‐Lopez, Douglas Hazel, Michael Levin   +6 more
wiley   +1 more source

18S rRNA: A Tale of the Tail [PDF]

Journal of Molecular Biology, 2011
More than 40 years ago, the Nomura group seduced the ribosome community with the breath-takingly simple reconstitution of the 30S ribosomal subunit from its component RNA and proteins (1). However, as with many seductions, the morning-after reality is sobering.
openaire   +3 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Hibridização in situ fluorescente: princípios básicos e perspectivas para o diagnóstico de doenças infecciosas em medicina veterinária

Arquivos do Instituto Biológico
Nesse manuscrito são discutidos aspectos relevantes sobre desenvolvimento da técnica de hibridização fluorescente in situ, seus princípios básicos, aplicações e perspectivas em medicina veterinária.
S.M.N. Neves, R.M.C. Guedes
doaj  

Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

eLife
Out of the several hundred copies of rRNA genes arranged in the nucleolar organizing regions (NOR) of the five human acrocentric chromosomes, ~50% remain transcriptionally inactive.
Qinyu Hao, Minxue Liu, Swapna Vidhur Daulatabad, Saba Gaffari, You Jin Song, Rajneesh Srivastava, Shivang Bhaskar, Anurupa Moitra, Hazel Mangan, Elizabeth Tseng, Rachel B Gilmore, Susan M Frier, Xin Chen, Chengliang Wang, Sui Huang, Stormy Chamberlain, Hong Jin, Jonas Korlach, Brian McStay, Saurabh Sinha, Sarath Chandra Janga, Supriya G Prasanth, Kannanganattu V Prasanth   +22 more
doaj   +1 more source

SuhB Associates with Nus Factors To Facilitate 30S Ribosome Biogenesis in Escherichia coli

mBio, 2016
A complex of highly conserved proteins consisting of NusB, NusE, NusA, and NusG is required for robust expression of rRNA in Escherichia coli.
Navjot Singh, Mikhail Bubunenko, Carol Smith, David M. Abbott, Anne M. Stringer, Ronald Shi, Donald L. Court, Joseph T. Wade   +7 more
doaj   +1 more source

Fluorescence in situ hybridisation detection of Lactobacillus plantarum group on olives to be used in natural fermentations [PDF]

, 2006
At present there are very few studies on the bacterial diversity of olives and on the importance of the microbial species for the fermentation of olives aimed to table olives production.
APONTE, MARIA, ERCOLINI, DANILO, MAURIELLO, GIANLUIGI, VILLANI, FRANCESCO   +3 more
core   +1 more source