Results 151 to 160 of about 696,870 (312)
Evaluation of MALDI-TOF MS, Sequencing of D2 LSU rRNA and Internal Transcribed Spacer Regions (ITS) for the Identification of Filamentous Fungi Isolated from a Pharmaceutical Facility
, 2023 Filipe Mercês Moreira, Pamalla de Araujo Pereira, Rebeca Vitória da Silva Lage de Miranda, Cristhiane Moura Falavina dos Reis, Lygia Maria Paulo da Silva Braga, Joyce Modesto de Andrade, Luciane Gomes do Nascimento, Josiane Machado Vieira Mattoso, Stephen Forsythe, Luciana Veloso da Costa, Marcelo Luiz Lima Brandão +10 moreopenalex +1 more sourcePolydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment
Advanced Science, EarlyView.A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu +11 morewiley +1 more sourceMetabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction
Advanced Science, EarlyView.SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song +11 morewiley +1 more sourceNIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects
Advanced Science, EarlyView.A novel multifunctional scaffold with photothermal effects is developed for infected bone defect repair. It facilitates angiogenesis and osteogenesis while eliminating bacteria through hyperthermia. Additionally, the scaffold promotes macrophage polarization from M1 to M2 via ROS scavenging, enhancing anti‐inflammatory activity. This study demonstrates Qifei Yang, Shu Lou, Yuan Zhang, Zhurun Fang, Changyue Xing, Wentao Wang, Minxuan Han, Zhendong Wang, Ben Zhong Tang, Ming Zhang +9 morewiley +1 more sourceSecondary Bile Acids Modified by Odoribacter Splanchnicus Alleviate Colitis by Suppressing Neutrophil Extracellular Trap Formation
Advanced Science, EarlyView.In ulcerative colitis, the loss of Odoribacter splanchnicus disrupts a microbiota‐metabolite‐neutrophil axis. Restoring this bacterium boosts lithocholic acid, which suppress neutrophil extracellular trap formation and eases colonic inflammation.Jing Xu, Jianhong Li, Xue Guo, Chen Huang, Yao Peng, Haoming Xu, Yingfei Li, Jingkui Xu, Jinxia Hu, Yitong Liao, Yuqiang Nie, Youlian Zhou +11 morewiley +1 more sourceFaecalibaculum rodentium Alleviates Ionizing Radiation‐Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate
Advanced Science, EarlyView.The model shows the probiotics screening and underlying mechanisms of F. rodentiumn in alleviating IR‐induced tissue injury. Stress‐induced STAT3 mitochondria localization decreases F. rodentium abundance and butyrate concentration. Supplementation of F.Hanyong Zhu, Hui Guo, Na Sun, Rui Xiao, Binbin Ji, Ruihan Jiang, Fuxing Dong, Chen Yao, Xuerong Wang, Rongqing Li, Jie Zhao, Xueqin Li, Shengzhe Gong, Yongqin Qin, Xin Chen, Yuchen Pan, Takayuki Ikezoe, Jing Yang +17 morewiley +1 more source