Results 31 to 40 of about 831 (147)

The Psychosocial Impact of the Decision to Undergo Risk-Reducing Salpingo-Oophorectomy Surgery in BRCA Mutation Carriers and the Role of Physician-Patient Communication

Current Oncology, 2023
Risk-reducing bilateral salpingo-oophorectomy (RRSO) is an effective prophylactic surgery provided to premenopausal women carrying BRCA1 or BRCA2 mutations and presenting an increased risk of developing breast or ovarian cancer. This procedure is related
Ana C. Alves-Nogueira, Daniela Melo, Carlos Carona, Margarida Figueiredo-Dias   +3 more
doaj   +1 more source

TP53 variants in p53 signatures and the clonality of STICs in RRSO samples

Journal of Gynecologic Oncology, 2022
Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of BRCA1/2. Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of high-grade serous carcinoma, whereas the significance of the p53 signature remains unclear.
Tomoko Akahane, Kenta Masuda, Akira Hirasawa, Yusuke Kobayashi, Arisa Ueki, Miho Kawaida, Kumiko Misu, Kohei Nakamura, Shimpei Nagai, Tatsuyuki Chiyoda, Wataru Yamagami, Shigenori Hayashi, Fumio Kataoka, Kouji Banno, Kokichi Sugano, Hajime Okita, Kenjiro Kosaki, Hiroshi Nishihara, Daisuke Aoki   +18 more
openaire   +2 more sources

Hysterectomy at the time of risk-reducing surgery in BRCA carriers

Gynecologic Oncology Reports, 2018
In this study, women at risk for BRCA were surveyed to understand their choice of prophylactic surgery and associated risk of uterine cancers. The study was conducted as an anonymous online web-based survey that assessed personal and family histories and
Navya Nair, Melissa Schwartz, Lisa Guzzardi, Nicki Durlester, Stephanie Pan, Jessica Overbey, Linus Chuang   +6 more
doaj   +1 more source

Pathologic findings at risk-reducing salpingo-oophorectomy (RRSO) in germline BRCA mutation carriers with breast cancer: significance of bilateral RRSO at the optimal age in germline BRCA mutation carriers [PDF]

Journal of Gynecologic Oncology, 2017
Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age. This study aimed to find the incidence of precursor lesions and cancer after RRSO.We retrospectively reviewed breast cancer patients identified as BRCA mutation carriers who underwent RRSO at Asan Medical Center, Seoul, Korea, from 2010 to 2014. From
Young-Jae Lee, Shin-Wha Lee, Kyu-Rae Kim, Kyung-Hae Jung, Jong-Won Lee, Yong-Man Kim   +5 more
openaire   +2 more sources

Theory‐based behavior change intervention to increase uptake of risk‐reducing salpingo‐oophorectomy in women with a BRCA1 or BRCA2 pathogenic variant: The PREVENT randomized controlled trial

Cancer Medicine, 2023
Objective To evaluate the effect of a theory‐based behavioral intervention delivered by genetic counselors on the uptake of risk‐reducing salpingo‐oophorectomy (RRSO) at 12 and 24 months by women with a BRCA1 or BRCA2 pathogenic variant (PV) compared to ...
Kelly A. Metcalfe, Tuya Pal, Steven A. Narod, Susan Armel, Salma Shickh, Kathleen Buckley, Scott T. Walters, Sarah Brennenstuhl, Anita Y. Kinney   +8 more
doaj   +1 more source

Risk of endometrial cancer after RRSO in BRCA 1/2 carriers: a multicentre cohort study

Clinical and Translational Oncology, 2023
Abstract Objective To know the risk of endometrial cancer (EC) in a population of women with BRCA 1/2 pathogenic or likely pathogenic variants after risk-reducing salpingo-oophorectomy (RRSO). Methods The study cohort included data from 857 women with BRCA mutations who ...
Helena Pla-Juher, Marta Pardo, Àngel J. Izquierdo, Esther Darder, Anna Carbó, Elisabet Munté, Sara Torres-Esquius, Judith Balmaña, Concepción Lázaro, Joan M. Brunet, Maria-Pilar Barretina-Ginesta   +10 more
openaire   +4 more sources

Selected features of breast and peritoneal cancers diagnosed in BRCA1 carriers after risk-reducing salpingo-oophorectomy

Hereditary Cancer in Clinical Practice, 2019
Background Since more than two decades Risk-reducing salpingo-oophorectomy (RRSO) is recommended and widely accepted by BRCA1/2 carriers as a method reducing ovarian cancer risk and improving survival rate.
Janusz Menkiszak, Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Aleksander Celewicz, Zbigniew Kojs, Mariusz Szajda, Maria Świniarska, Ryszard Bedner, Anna Jurczak, Marta Celewicz, Monika Cieszyńska, Jan Lubiński, Jacek Gronwald   +12 more
doaj   +1 more source

Hereditary Women’s Cancer: Management and Risk-Reducing Surgery

Medicina, 2023
Hereditary women’s syndromes due to inherited mutations result in an elevated risk of developing gynecological cancers over the lifetime of affected carriers.
Carmine Conte, Silvia Pelligra, Giuseppe Sarpietro, Giuseppe Dario Montana, Luigi Della Corte, Giuseppe Bifulco, Canio Martinelli, Alfredo Ercoli, Marco Palumbo, Stefano Cianci   +9 more
doaj   +1 more source

Change in practice of RRSO consults and procedures during the COVID-19 pandemic (563)

Gynecologic Oncology, 2022
Objectives: To investigate the impact of the Covid-19 pandemic on risk-reducing salpingo-oophorectomies (RRSO). Methods: An electronic survey was sent out to 1,127 full members of the Society of Gynecologic Oncology in August 2021. Survey data included physician characteristics, practice location, and self-reported subjective and objective data about ...
O’Mara, Alana, Kurian, Allison, Benedict, Catherine, Diver, Elisabeth   +3 more
openaire   +1 more source

Risk-reducing decisions regarding germline BRCA pathogenic variant: focusing on the timing of genetic testing and RRSO

Journal of Medical Genetics, 2023
Background In Japan, the public insurance policy was revised in 2020 to cover hereditary breast and ovarian cancer (HBOC), including genetic testing and surveillance, for patients with breast cancer (BC). Consequently, the demand for risk-reducing salpingo-oophorectomy (RRSO) has increased.
Akiko Abe, Hidetaka Nomura, Atsushi Fusegi, Mayu Yunokawa, Arisa Ueki, Eri Habano, Hiromi Arakawa, Keika Kaneko, Yuko Minoura, Hitoshi Inari, Takayuki Ueno, Hiroyuki Kanao   +11 more
openaire   +2 more sources