Results 41 to 50 of about 831 (147)

292 Efficacy of RRSO in BRCA carriers and clinical outcomes of follow-up in patients with isolated STIC [PDF]

Prevention of gynaecologic cancer, 2021
Introduction/Background* Serous Tubal Intraepithelial Carcinoma (STIC) is a non-invasive subtype of high-grade serous carcinoma (HGSC), usually located at the tubo-peritoneal junction and currently considered the precursor lesion of HGSC. The management of STIC diagnosed after Risk-Reducing Salpingo-Oophorectomy (RRSO) in women with BRCA-carriers ...
G Spagnol, M Noventa, G Bonaldo, M Marchetti, S Zovato, L Alessandrini, A Guerriero, S Tognazzo, R Tozzi, C Saccardi   +9 more
openaire   +1 more source

Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study

Current Oncology, 2023
Pathogenic variants (PVs) in BRCA1 and BRCA2 increase the lifetime risks of breast and ovarian cancer. Guidelines recommend breast screening (magnetic resonance imaging (MRI) and mammogram) or risk-reducing mastectomy (RRM) and salpingo-oophorectomy ...
Aimee Roebothan, Kerri N. Smith, Melanie Seal, Holly Etchegary, Lesa Dawson   +4 more
doaj   +1 more source

Risk-reducing salpingo-oophorectomy among Chinese women at increased risk of breast and ovarian cancer

Journal of Ovarian Research, 2023
Background Risk-reducing salpingo-oophorectomy (RRSO) is recommended for women at increased risk of breast and ovarian cancer. We launched a prospective study of women receiving RRSO, including those with mutations in genes beyond BRCA1/2.
Zheng Feng, Ke Zuo, Xingzhu Ju, Xiaojun Chen, Wentao Yang, Hao Wen, Lin Yu, Xiaohua Wu   +7 more
doaj   +1 more source

Scar-Free Laparoscopy in BRCA-Mutated Women

Medicina, 2022
Background and Objectives: BRCA 1 and 2 mutations have a cumulative risk of developing ovarian cancer at 70 years of 41% and 15%, respectively, while a cumulative risk of breast cancer by 80 years of age was 72% for BRCA1 mutation carriers and 69% for ...
Stefano Restaino, Angelo Finelli, Giulia Pellecchia, Anna Biasioli, Jessica Mauro, Carlo Ronsini, Monica della Martina, Martina Arcieri, Luigi Della Corte, Felice Sorrentino, Lorenza Driul, Giuseppe Vizzielli   +11 more
doaj   +1 more source

Basic knowledge for counseling patients undergoing risk-reducing salpingo-oophorectomy [PDF]

Obstetrics & Gynecology Science
Significant progress has been made in the molecular diagnosis of cancer. It provides personalized medicine, including cancer diagnosis, prognosis, targeted therapy, and risk detection.
Jihye Kim, Chel Hun Choi
doaj   +1 more source

Genetic Counseling, Screening and Risk-Reducing Surgery in Patients with Primary Breast Cancer and Germline BRCA Mutations: Unmet Needs in Low- and Middle-Income Countries

European Journal of Breast Health, 2022
Objective:Worldwide genetic counseling practices are variable and often not reported in low- and middle-income countries (LMICs). We present the follow-up genetic counseling, breast screening, risk-reducing salpingo-oophorectomy (RRSO) and contralateral ...
Hiba A. Moukadem, Ahmad Al Masry, Rula W. Atwani, Firas Kreidieh, Lana E. Khalil, Rita Saroufim, Sarah Daouk, Iman Abou Dalle, Nagi S. El Saghir   +8 more
doaj   +1 more source

What Happens After Menopause (WHAM)? A Progress Report of a Prospective Controlled Study of Women After Pre‐Menopausal Risk‐Reducing Bilateral Salpingo‐Oophorectomy

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price, Pauline M. Maki, Samar R. El Khoudary, Alison Brand, Rakibul M. Islam, Susan M. Domchek, Hadine Joffe, Gita D. Mishra, Katrina M. Moss, Fiona C. Baker, Sabine Braat, John D. Wark, Martha Hickey   +12 more
wiley   +1 more source

Sexual Function, Activity and Distress 24 Months After Surgical Menopause: What Happens After Menopause (WHAM)—A Prospective Controlled Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine the effect of surgical menopause (risk‐reducing salpingo‐oophorectomy, RRSO) on sexual function and the modifying effects of HRT. Design Prospective observational study of women undergoing RRSO and age‐matched comparison group who retained their ovaries. Setting High‐risk clinics and general population.
Martha Hickey, Trevor Tejada‐Berges, Susan M. Domchek, Efrosinia O. Krejany, Alison Brand, Peixuan Li, Sabine Braat, Sheryl Kingsberg   +7 more
wiley   +1 more source

The fallopian tube as origin of ovarian cancer: Change of diagnostic and preventive strategies

Cancer Medicine, 2020
Ovarian cancer is the leading cause of gynecologic cancer death in the world, and its prevention and early diagnosis remain the key to its treatment, especially for high‐grade serous carcinoma (HGSC).
Satoru Kyo, Noriyoshi Ishikawa, Kohei Nakamura, Kentaro Nakayama   +3 more
doaj   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source