Results 61 to 70 of about 831 (147)

Challenges in Managing Patients with Hereditary Cancer at Gynecological Services

Obstetrics and Gynecology International, 2019
Aim. To reveal current problems and challenges faced by our gynecologic services department in managing patients with hereditary cancers. Methods.
Mako Ueda, Hiroshi Tsubamoto, Mina Kashima-Morii, Yoshitaka Torii, Mariko Kamihigashi, Yu Wakimoto, Nami Nakagomi, Tomoko Hashimoto-Tamaoki, Hideaki Sawai, Hiroaki Shibahara   +9 more
doaj   +1 more source

“It was a no-brainer”: A qualitative study of factors driving previvors’ decision-making when considering risk-reducing salpingectomy with delayed oophorectomy

Gynecologic Oncology Reports, 2022
Objective: Previvors are becoming more aware of the option of risk-reducing salpingectomy with delayed oophorectomy (RRS-DO) to mitigate their risk of ovarian cancer.
Caroline Gellman, Charlotte Ezratty, Julia Schwarz, Valentin Kolev, Stephanie V. Blank   +4 more
doaj   +1 more source

Implementation of opportunistic salpingectomy for ovarian cancer prevention: Analyzing clinical practice and key characteristics

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 8, Page 1539-1549, August 2025.
Counseling and performance rates of opportunistic salpingectomy increased significantly in Dutch hospitals from 2019 to 2022. However, substantial variability persists due to patient, surgical, and physician characteristics. Targeted improvements are needed to standardize opportunistic salpingectomy as a preventive strategy against ovarian cancer ...
Charlotte Fisch, Malou E. Gelderblom, Brigitte Slangen, Angèle L. M. Oei, Alexandra A. van Ginkel, Huy Ngo, Joanne de Hullu, Jurgen Piek, Rosella Hermens   +8 more
wiley   +1 more source

Cost effectiveness of bilateral risk-reducing mastectomy and salpingo-oophorectomy

European Journal of Medical Research, 2019
Background Growing demand for risk-reducing surgery in individuals with inherited susceptibility to cancer leads to the question whether these procedures are cost effective for the executing hospitals. This study compared the clinical costs for bilateral
Michael G. Schrauder, Lisa Brunel-Geuder, Lothar Häberle, Marius Wunderle, Juliane Hoyer, Roland Csorba, André Reis, Rüdiger Schulz-Wendtland, Matthias W. Beckmann, Michael P. Lux   +9 more
doaj   +1 more source

Standardization, Education, and Resourcing: The Way Forward for Implementing Polygenic Risk Scores in Hereditary Breast and Ovarian Cancer

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT The clinical utility and implementation of polygenic risk scores (PRS) in the setting of personalized risk assessment for hereditary breast and ovarian cancer (HBOC) continues to be investigated. We aimed to explore and analyze genetic healthcare providers' perspectives toward national implementation in Australia, acknowledging the vitality of
Rebecca Purvis, Natalie Taylor, Mary‐Anne Young, Paul James, Laura E. Forrest   +4 more
wiley   +1 more source

Simultaneous bilateral mastectomy and RRSO for BRCA2-positive non-invasive breast cancer in Japan: a case report and analysis of initial experience

Hereditary Cancer in Clinical Practice, 2023
Background In Japan, genetic testing, surveillance, and risk-reducing surgery for hereditary breast and ovarian cancer (HBOC) syndrome have been covered by the Japanese national insurance system since April 2020.
Aya Tanaka, Megumi Matsumoto, Mami Takao, Shoko Miura, Yuri Hasegawa, Ryota Otsubo, Hiroko Hayashi, Ichiro Isomoto, Kiyonori Miura, Takeshi Nagayasu   +9 more
doaj   +1 more source

Pathogenesis of peritoneal high‐grade serous carcinoma after risk‐reducing surgery: a systematic review

The Journal of Pathology: Clinical Research, Volume 11, Issue 4, July 2025.
Abstract Germline BRCA1/2 pathogenic variant carriers have an increased risk for high‐grade serous carcinoma (HGSC) and are therefore advised to have risk‐reducing salpingo‐oophorectomy around the age of 40. However, a risk of 0.9% to develop peritoneal HGSC remains in these women, which increases to 27.5% when serous tubal intraepithelial carcinoma ...
Tamar A Gootzen, Anouk B Bouwmeester, Joanne A de Hullu, Jurgen MJ Piek, Jeroen AWM van der Laak, Michiel Simons, Miranda P Steenbeek   +6 more
wiley   +1 more source

Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer

Cancer Science, Volume 116, Issue 4, Page 1048-1058, April 2025.
This study included 7278 Asian patients and revealed that those carrying BRCA1/2 pathogenic variants had significantly shorter 10‐year invasive disease‐free survival and relapse‐free survival than noncarriers. No significant difference in survival was observed in patients with non‐BRCA1/2 pathogenic variants.
Rui Kitadai, Shu Yazaki, Aya Kuchiba, Takashi Yamanaka, Sho Shiino, Chisako Yamauchi, Kenichi Harano, Motonobu Saito, Yosuke Hirotsu, Hisaki Aiba, Teruhiko Yoshida, Ryuji Hamamoto, Chikako Shimizu, Akihiko Shimomura, Yuki Kojima, Tatsunori Shimoi, Yukihide Momozawa, Kazuki Sudo, Masayuki Yoshida, Kuniko Sunami, Megumi Hori, Kota Katanoda, Yoko Shimada, Yuji Yamashita, Takahiro Kogawa, Takeshi Murata, Saori Fujiwara, Yohei Miyagi, Hiroshi Nakagomi, Kazunoshin Tachibana, Masao Omata, Tohru Ohtake, Akihiko Suto, Tatsuya Onishi, Yoichi Naito, Toshinari Yamashita, Kan Yonemori, Takashi Kohno, Kouya Shiraishi   +38 more
wiley   +1 more source

Study on the psychosocial aspects of risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 mutation carriers in Japan: a preliminary report [PDF]

Japanese Journal of Clinical Oncology, 2015
This study investigated the psychosocial aspects of risk-reducing salpingo-oophorectomy in Japan.The subjects were 16 patients who underwent risk-reducing salpingo-oophorectomy at the Cancer Institute Hospital. Worry about cancer, emotional state and cancer-specific distress level were evaluated using a four-point Likert scale, the Profile of Mood ...
Mika, Shigehiro, Mizuho, Kita, Sayoko, Takeuchi, Yuumi, Ashihara, Masami, Arai, Hitoshi, Okamura   +5 more
openaire   +2 more sources

Pilot study of the effect of surgical menopause on bone mineral density and quality in patients with gynecological malignancies

Journal of Obstetrics and Gynaecology Research, Volume 51, Issue 1, January 2025.
Abstract Aim To investigate the effects of surgical menopause on bone mineral density and bone quality because bilateral salpingo‐oophorectomy for the treatment of gynecological malignancies is common even in premenopausal patients. This study is prospective one of bone mineral density and quality measurements after surgery for perimenopausal ...
Kanae Matsuno, Kazu Ueda, Mitsuru Saito, Misato Kamii, Akina Tsuda, Ayako Kawabata, Asuka Morikawa, Aikou Okamoto   +7 more
wiley   +1 more source