Results 51 to 60 of about 7,589 (218)

RSPOs facilitated HSC activation and promoted hepatic fibrogenesis

Oncotarget, 2016
Roof plate-specific spondin (RSPO) proteins are potent Wnt pathway agonists and involve in a broad range of developmental and physiological processes. This study investigated the activities and mechanisms of RSPOs in liver fibrogenesis, especially in hepatic stellate cell (HSC) activation.
Yin, Xinguang, Yi, Huixing, Wang, Linlin, Wu, Wanxin, Wu, Xiaojun, Yu, Linghua   +5 more
openaire   +3 more sources

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3788-3806, May 2026.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

LGR5 is expressed by Ewing sarcoma and potentiates Wnt/β-catenin signaling

Frontiers in Oncology, 2013
Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of putative stem cell origin that predominantly occurs in children and young adults. Although most patients with localized ES can be cured with intensive therapy, the clinical course is ...
Christopher A Scannell, Christopher A Scannell, Elisabeth A Pedersen, Jack T Mosher, Melanie Anne Krook, Lauren A Nicholls, Breelyn A Wilky, David M. Loeb, Elizabeth R Lawlor, Elizabeth R Lawlor   +9 more
doaj   +1 more source

Towards red listing understudied tropical insects: A case study of the dung beetles of Sabah, Malaysian Borneo

Insect Conservation and Diversity, Volume 19, Issue 3, Page 511-529, May 2026.
We performed an IUCN Red List assessment for 159 dung beetle species from Sabah, Malaysian Borneo. Due to the lack of population demographic data, only Criterion B (i.e. geographic range) could be applied. Our findings show that the IUCN Red List Criteria can be applied to insect species based solely on occurrence data but highlight the importance of ...
Xin Rui Ong, Marx W.‐H. Yim, Li Yuen Chiew, Arthur Y. C. Chung, Catherine Numa, Eleanor M. Slade   +5 more
wiley   +1 more source

Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling.

PLoS ONE, 2020
Secreted R-spondin1-4 proteins (RSPO1-4) orchestrate stem cell renewal and tissue homeostasis by potentiating Wnt/β-catenin signaling. RSPOs induce the turnover of negative Wnt regulators RNF43 and ZNRF3 through a process that requires RSPO interactions ...
Vincent C Luca, Yi Miao, Xingnan Li, Michael J Hollander, Calvin J Kuo, K Christopher Garcia   +5 more
doaj   +1 more source

An assessment tool and integrated index for sustainable oil palm production [PDF]

, 2010
Many prominent sectors of the international agricultural commodities market have been calling upon their stakeholders to define and implement social responsibility and sustainability benchmarks, aiming at product quality and production practices ...
Caliman, Jean-Pierre, Stachetti Rodrigues, Géraldo, Verwilghen, Aude   +2 more
core  

Formulation and evaluation of multiparticulate system for chronotherapeutic delivery of salbutamol sulphate

Journal of Pharmacy and Bioallied Sciences, 2012
Solution layering technique was used to prepare pellets of Salbutamol Sulphate. A multiparticulate system was prepared with pH independent and pH dependent coatings, and evaluated as pulsatile drug delivery system. Salbutamol sulphate release was studied
M Pallavi Chaudhari, D Pravin Chaudhari
doaj   +1 more source

Green Ologbo : an integrated project for sustainable development of oil palm plantation [PDF]

, 2007
Presco Plc, a member of the Siat group, is a company operating in Nigeria producing and processing oil palm for the domestic market. The company decided to extend its plantation and implement a sustainable project, the "Green Ologbo" project, promoting ...
Chambon, Bénédicte, McAleer, V., Renevot, G., Soengaz Lopez, B., Verwilghen, Aude   +4 more
core  

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin [PDF]

, 2014
The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and ...
Chen, Maorong, Gilbert, Robert J. C., He, Xi, Jones, E. Yvonne, Krastev, Christos, MacDonald, Bryan T., Xu, Yang, Zebisch, Matthias   +7 more
core   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, Volume 255, Issue 3, Page 340-361, March 2026.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source