Results 41 to 50 of about 1,860 (177)
RSPOs facilitated HSC activation and promoted hepatic fibrogenesis
Oncotarget, 2016 Roof plate-specific spondin (RSPO) proteins are potent Wnt pathway agonists and involve in a broad range of developmental and physiological processes. This study investigated the activities and mechanisms of RSPOs in liver fibrogenesis, especially in hepatic stellate cell (HSC) activation.
Yin, Xinguang +5 more
openaire +3 more sources
Histopathology, EarlyView.The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty +7 more
wiley +1 more source
Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells [PDF]
Genes, 2018 In this review, we address aspects of Wnt, R-Spondin (RSPO) and Hippo signalling, in both healthy and transformed intestinal epithelium. In intestinal stem cells (ISCs), the Wnt pathway is essential for intestinal crypt formation and renewal, whereas RSPO-mediated signalling mainly affects ISC numbers.
Kriz, Vitezslav, Korinek, Vladimir
openaire +2 more sources
Remaking State Power Through a Paraquat Ban in Malaysia
Journal of Agrarian Change, EarlyView.ABSTRACT This paper examines the role of the state in its ability to enact environmental regulations. Specifically, this study investigates how Malaysian state actors changed, shifted and betrayed various, oftentimes competing interests to ban paraquat, an acutely toxic herbicide.
Caitlyn Sears
wiley +1 more source
Regulation &Governance, EarlyView.ABSTRACT Governance of sustainable development increasingly relies on voluntary standards and commitments, the credibility and effectiveness of which hinge on accountability—ensuring actors align with shared goals and follow through on them. However, voluntary initiatives operate outside traditional control structures and blend elements of state ...
Elina Vikstedt +3 more
wiley +1 more source
Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling.
PLoS ONE, 2020 Secreted R-spondin1-4 proteins (RSPO1-4) orchestrate stem cell renewal and tissue homeostasis by potentiating Wnt/β-catenin signaling. RSPOs induce the turnover of negative Wnt regulators RNF43 and ZNRF3 through a process that requires RSPO interactions ...
Vincent C Luca +5 more
doaj +1 more source
Regulation &Governance, EarlyView.ABSTRACT Voluntary sustainability standards (VSS)—such as Fairtrade International and the Forest Stewardship Council—aim to improve sustainability in global supply chains by setting high social and environmental standards and certifying businesses that adopt them.
Elizabeth A. Bennett
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source
LGR5 is expressed by Ewing sarcoma and potentiates Wnt/β-catenin signaling
Frontiers in Oncology, 2013 Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of putative stem cell origin that predominantly occurs in children and young adults. Although most patients with localized ES can be cured with intensive therapy, the clinical course is ...
Christopher A Scannell +9 more
doaj +1 more source
Jurnal Agro Industri PerkebunanImplementing RSPO (Roundtable on Sustainable Palm Oil) standards is one way to address the challenges palm oil products face in competing in the global market.
Muhamad Yazid Bustomi +5 more
doaj +1 more source