Results 91 to 100 of about 161,851 (302)

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

A proof of concept for structure-based vaccine design targeting RSV in humans

Science, 2019
Building a better RSV vaccine Respiratory syncytial virus (RSV) causes severe respiratory disease, especially in infants and the elderly. However, attempts to produce effective human vaccines have largely been unsuccessful.
M. Crank, T. Ruckwardt, Man Chen, Kaitlyn M. Morabito, Emily Phung, Pamela J. M. Costner, L. Holman, S. Hickman, N. Berkowitz, Ingelise J. Gordon, G. Yamshchikov, M. Gaudinski, Azad Kumar, Lauren A. Chang, Syed M. Moin, Juliane P. Hill, Anthony T. DiPiazza, Richard M. Schwartz, L. Kueltzo, J. Cooper, Peifeng Chen, Judy A. Stein, K. Carlton, J. Gall, M. Nason, P. Kwong, Grace L. Chen, J. Mascola, J. McLellan, J. Ledgerwood, B. Graham   +30 more
semanticscholar   +1 more source

The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV): A systematic review and meta-analysis

Journal of Global Health, 2020
Background Respiratory syncytial virus (RSV) is the predominant viral cause of childhood pneumonia. Little is known about the role of viral-coinfections in the clinical severity in children infected with RSV.
You Li, P. Pillai, F. Miyake, H. Nair
semanticscholar   +1 more source

Enhancing Volatility Prediction: A Wavelet‐Based Hierarchical Forecast Reconciliation Approach

Journal of Forecasting, EarlyView.
ABSTRACT Forecasting realized volatility (RV) has been widely studied, with numerous techniques developed to enhance predictive accuracy. Among these techniques, the use of RV decompositions based on intraday asset returns has been applied. However, the use of a frequency‐based decomposition, which provides unique insights into the dynamics of RV ...
Adam Clements, Ajith Perera
wiley   +1 more source

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, EarlyView.
What's New? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

The cost-effectiveness of palivizumab in infants with cystic fibrosis in the Canadian setting: A decision analysis model

Human Vaccines & Immunotherapeutics, 2017
Background: Children with cystic fibrosis (CF) are at higher risk of severe respiratory syncytial virus (RSV) infection, which can lead to a decline in lung function.
Ashleigh A. McGirr, Kevin L. Schwartz, Upton Allen, Melinda Solomon, Beate Sander   +4 more
doaj   +1 more source

Actual data regarding the impact of viral respiratory co-infection (Covid-19 and flu/Respiratory Syncytial Virus-RSV)- A systematic review [PDF]

Balneo and PRM Research Journal
Background. The impact of SARS-CoV-2 infection alongside with influenza and RSV, the major viral agents in pediatric disordes, may be an important concern to the healthcare system. Clini-cal outcomes of the interaction are unknown.
Alina-Maria Robu, Gelu Onose, Maria-Teodora Ulinici, Rață Andrei, Anca Bălănescu, Valentina-Daniela Comănici, Tatiana Ciomârtan, Ioana-Florentina Codreanu   +7 more
doaj   +1 more source

Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study

Journal of Clinical Microbiology, 2020
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide.
D. Tabor, F. Fernandes, Annefleur C Langedijk, Deidre Wilkins, R. Lebbink, A. Tovchigrechko, A. Ruzin, L. Kragten-Tabatabaie, Hong Jin, M. Esser, L. Bont, M. Abram, Christina Anouk Marco C. Joanne G. Frank E.J. Marije P. Anne Naaktgeboren Evers Viveen Wildenbeest Coenjaerts H   +12 more
semanticscholar   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

The Journey to an RSV Vaccine.

Annals of Allergy, Asthma & Immunology, 2020
OBJECTIVE The high burden associated with respiratory syncytial virus (RSV), has made the development of RSV vaccine(s) a global health high priority.
A. Mejías, R. Rodríguez-Fernández, S. Oliva, M. Peeples, O. Ramilo   +4 more
semanticscholar   +1 more source