Efficacy and Safety of Messenger RNA Vaccines
ABSTRACT Background and Aims The rapid development of mRNA vaccines has revolutionized infectious disease prevention and cancer immunotherapy. While their efficacy is well established, concerns about safety and immunopathological risks persist. This study aims to evaluate the immunogenicity, safety profiles, and design considerations of mRNA vaccines ...
Kesaobaka Batisani, David Chisompola
wiley +1 more source
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
Regulation of antiviral immunity by PD-1 during respiratory syncitial virus infection and upon vaccination. [PDF]
Rodríguez-Guilarte L +8 more
europepmc +1 more source
Pharmacy‐Based Immunization Delivery: A Comprehensive History and Current Challenges
ABSTRACT Pharmacists and their teams have a long history of involvement with vaccines. This paper describes the contributions of pharmacy‐based immunization delivery in the United States from the 1800's to date. Early activities centered around storage and distribution of antitoxins and vaccines. From the 1950s through the early 1990s, pharmacists were
Jean‐Venable R. Goode +4 more
wiley +1 more source
Hospitalization Burden Estimates of Respiratory Syncytial Virus With Adjustment for Case Underascertainment in Adults Aged 18 to 65 Years in High-Income Countries: A Systematic Review, Meta-Analysis, and Modeling Study. [PDF]
Li Y +10 more
europepmc +1 more source
Microplastics as a Silent Threat to Child Neurodevelopment: Evidence and Perspectives on Autism
Microplastics and nanoplastics can likely cross various biological barriers and promote the development of oxidative stress and neuroinflammation, and they can also interfere with crucial events during brain development. Although none of these effects are causally linked to autism spectrum disorders, the microparticles and nanoparticles are the first ...
David Santos Grillo +5 more
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Acceptance of the respiratory syncytial virus infant monoclonal antibody nirsevimab among post-partum women in Italy. [PDF]
Angelillo S +4 more
europepmc +1 more source
Viral Detection and Clinical Disease Features in Pediatric Chronic Rhinosinusitis
ABSTRACT Objectives Chronic rhinosinusitis (CRS) results from complex host‐environment interactions with microbiome dysbiosis and viral infections postulated to drive inflammation and anatomic remodeling. This study investigates the impact of viral presence on pediatric sinonasal disease and clinical outcomes.
Mary C. Wilding +7 more
wiley +1 more source
Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj +7 more
wiley +1 more source
Estimated efficacy of the adjuvanted RSVPreF3 vaccine against diverse and worldwide predominant RSV strains, irrespective of RSV F protein variation: results of a post-hoc analysis from the AReSVi-006 trial. [PDF]
De Smedt J +12 more
europepmc +1 more source

