Organoids: From Bench to Bedside Applications
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Clinical characterization of patients and genomic description of respiratory syncytial virus in adults and paediatric patients in a northeastern Mexican population. [PDF]
Hernandez-Balboa CL +12 more
europepmc +1 more source
Innate immunity shapes the persistent transmission of plant viruses by insect vectors
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley +1 more source
Hyaluronic acid and/or pectin (crosslinked by calcium lactate) allowed the development of Bentophen200 extract‐loaded buccal films. Given i) the antioxidant power of the polyphenols‐rich extract optimized via multiple maceration of waste bentonite and ii) the flexibility, mucoadhesivity, and suitability of the films for oromucosal application, they can
Giulia Di Prima +2 more
wiley +1 more source
Respiratory syncytial virus infections and myocardial injury: the GEMINI Initiative. [PDF]
McAlister FA +3 more
europepmc +1 more source
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols. Recent years have witnessed substantial progress in clinical
Committee of Pediatrics +16 more
wiley +1 more source
Bivalent RSVpreF effectiveness against RSV-associated hospital or emergency department care over two seasons: a retrospective test-negative case control study. [PDF]
Tartof SY +20 more
europepmc +1 more source
The economic burden of respiratory syncytial virus and other acute respiratory infections among children <2 years old seeking care at a tertiary facility in Accra, Ghana. [PDF]
Shaaban FL +6 more
europepmc +1 more source
Expenditures attributable to infant lower respiratory tract infection due to respiratory syncytial virus in the US: A real-world study using the PharMetrics Plus Database, 2015-2023. [PDF]
Averin A +4 more
europepmc +1 more source

