Results 51 to 60 of about 32,704 (143)

Location matters in RSV protection

Cell Host & Microbe, 2022
In this issue of Cell Host & Microbe, Zohar et al., 2022 show that immunization of non-human primates with six different candidate respiratory syncytial virus vaccines resulted in distinct antibody profiles and variable levels of protection. Using a systems serology approach, they identified compartment-specific antibody-mediated correlates of ...
openaire   +3 more sources

Protective and Harmful Immunity to RSV Infection.

Annual Review of Immunology, 2017
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by
P. Openshaw, C. Chiu, F. Culley, C. Johansson   +3 more
semanticscholar   +1 more source

Transient opening of trimeric prefusion RSV F proteins

Nature Communications, 2019
The respiratory syncytial virus (RSV) F glycoprotein is a class I fusion protein that mediates viral entry and is a major target of neutralizing antibodies.
M. Gilman, Polina Furmanova-Hollenstein, Gabriel Pascual, Angélique B. van ‘t Wout, J. Langedijk, J. McLellan   +5 more
semanticscholar   +1 more source

Clinical Features, Severity, and Incidence of RSV Illness During 12 Consecutive Seasons in a Community Cohort of Adults ≥60 Years Old

Open Forum Infectious Diseases, 2018
Background The epidemiology and burden of respiratory syncytial virus (RSV) illness are not well defined in older adults. Methods Adults ≥60 years old seeking outpatient care for acute respiratory illness were recruited from 2004–2005 through 2015–2016 ...
E. Belongia, J. King, B. Kieke, Joanna Pluta, A. Al-Hilli, J. Meece, V. Shinde   +6 more
semanticscholar   +1 more source

Role and Virology of RSV and RSV RNA Polymerase

The FASEB Journal, 2021
Avary Andrews, Lan Nguyen, Tina Link, Aryn Wright, Abhishek Kona, Joseph A. Fisher   +5 more
openaire   +1 more source

Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development

Frontiers in Immunology, 2019
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease in young children and a substantial contributor to respiratory tract disease throughout life and as such a high priority for vaccine development.
Seyhan Boyoglu-Barnum, T. Chirkova, L. Anderson   +2 more
semanticscholar   +1 more source

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

Science immunology, 2016
Anti–RSV F antibody repertoire profiling reveals new opportunities for vaccine design and passive therapy. RSV antibodies in profile Respiratory syncytial virus (RSV) causes cold-like symptoms in healthy adults but can have serious complications in both ...
M. Gilman, C. Castellanos, Man Chen, Joan O. Ngwuta, E. Goodwin, Syed M. Moin, V. Mas, J. Melero, P. Wright, B. Graham, J. McLellan, L. Walker   +11 more
semanticscholar   +1 more source

First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector–Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults

Clinical Infectious Diseases, 2019
Background Respiratory syncytial virus (RSV) disease is a major cause of infant morbidity and mortality. This Phase I, randomized, observer-blind, placebo- and active-controlled study evaluated an investigational vaccine against RSV (ChAd155-RSV) using ...
P. Cicconi, Claire Jones, E. Sarkar, L. Silva-Reyes, P. Klenerman, C. D. de Lara, Claire L Hutchings, P. Moris, M. Janssens, L. Fissette, M. Picciolato, A. Leach, Antonio Gonzalez-Lopez, I. Dieussaert, M. Snape   +14 more
semanticscholar   +1 more source

Tumor Growth and Antibodies after RSV-Challenge in Normal Chickens and in Chickens Congenitally Infected with Avian Leukosis Virus [PDF]

, 1977
Paul A. Meyers, Louis F. Qualtiere
openalex   +1 more source

Safety and Immunogenicity of the Respiratory Syncytial Virus Vaccine RSV/ΔNS2/Δ1313/I1314L in RSV-Seronegative Children

Journal of Infectious Diseases, 2019
Background Respiratory syncytial virus (RSV) is the leading global cause of severe pediatric acute respiratory tract illness, and a vaccine is needed. RSV/ΔNS2/Δ1313/I1314L contains 2 attenuating elements: (1) deletion of the interferon antagonist NS2 ...
R. Karron, C. Luongo, Jocelyn San Mateo, Kimberli A Wanionek, P. Collins, U. Buchholz   +5 more
semanticscholar   +1 more source