Results 41 to 50 of about 8,315 (142)

Associations of maternal and placental extracellular vesicle miRNA with preeclampsia

Frontiers in Cell and Developmental Biology, 2023
Introduction: Gestational vascular complications (GVCs), including gestational hypertension and preeclampsia, are leading causes of maternal morbidity and mortality.
Anat Aharon, Anat Aharon, Anat Aharon, Anat Aharon, Annie Rebibo-Sabbah, Rawan Sayed Ahmad, Ayelet Dangot, Tali Hana Bar-Lev, Benjamin Brenner, Benjamin Brenner, Adi Halberthal Cohen, Chen Ben David, Zeev Weiner, Zeev Weiner, Ido Solt, Ido Solt   +15 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Improved Performance of RT-PPP During Communication Outages Based on Position Constraints and Stochastic Model Optimization

Remote Sensing
In the practical application of Real-Time Precise Point Positioning (RT-PPP), the outages in receiving spatial state representation (SSR) information due to communication anomalies can result in a decrease or even divergence of the positioning accuracy ...
Xiaosong Liu, Lin Zhao, Fuxin Yang, Jie Zhang, Jinjian Shi, Chuanlei Zheng   +5 more
doaj   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Predicting disease progression from the rate of bodyweight change in nasopharyngeal carcinoma patient during radiotherapy

Scientific Reports
Bodyweight loss is a common occurrence in Nasopharyngeal Carcinoma (NPC) patients during Radiotherapy (RT). Previous studies found that the prognostic value of percentage weight loss (pWL) during RT is not credible.
Jiachen Sun, Sai kit Edmond Lam, Xinzhi Teng, Jiang Zhang, Francis Kar-ho Lee, Celia Wai-yi Yip, James Chung-hang Chow, Victor Ho-fun Lee, Ying Sun, Jing Cai   +9 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Assessment of Affordable Real-Time PPP Solutions for Transportation Applications

Algorithms
With the availability of multi-frequency, multi-constellation global navigation satellite system (GNSS) modules, precise transportation applications have become attainable.
Mohamed Abdelazeem, Amgad Abazeed, Abdulmajeed Alsultan, Amr M. Wahaballa   +3 more
doaj   +1 more source

Dynamics of λ-cyhalothrin disappearance and expression of selected P450 genes in bees depending on the ambient temperature

Open Chemistry, 2021
Temperature has a significant influence on the action of pyrethroids, and their effect increases with decreasing ambient temperature. Using gas chromatography, we assessed the degradation rate of λ-cyhalothrin, active ingredients (AI) of Karate Zeon 050 ...
Piechowicz Bartosz, Kobielska Marika, Koziorowska Anna, Podbielska Magdalena, Szpyrka Ewa, Pieniążek Marcin, Potocki Leszek   +6 more
doaj   +1 more source

Low-Cost IMU and Odometer Tightly Augmented PPP-B2b-Based Inter-Satellite Differenced PPP in Urban Environments

Remote Sensing, 2022
Since 23 June 2020, BDS-3 has been entirely operated and obtained the ability of global PNT (Positioning, Navigation, and Timing) services. Afterward, real-time Precise Point Positioning (PPP) service is available in China’s surrounding areas via BDS-3 ...
Yu Min, Zhouzheng Gao, Jie Lv, Ruohua Lan, Qiaozhuang Xu, Cheng Yang   +5 more
doaj   +1 more source