Results 91 to 100 of about 119,552 (307)

Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]

, 2003
Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S., Edwards, J., Krishnan, S., Witton, C.J.   +3 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Lelkészeknek – a lelkészkép – lelkészi identitás kérdése az önértelmezésünk rögös útján –

Studia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica, 2016
The Problem of Self-image and Identity by Pastors. The problem of self-image and identity is an issue that seems to trouble theologian more and more, but pastors less and less.
Miklós KOCSEV
doaj  

PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy

Molecular Cancer, 2018
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and dysregulation of this pathway is implicated in the development and ...
Nahal Haddadi, Yiguang Lin, Glena Travis, A. Simpson, E. McGowan, N. Nassif   +5 more
semanticscholar   +1 more source

Real-Time PPP-RTK Performance Analysis Using Ionospheric Corrections from Multi-Scale Network Configurations

Italian National Conference on Sensors, 2020
The long convergence time required to achieve high-precision position solutions with integer ambiguity resolution-enabled precise point positioning (PPP-RTK) is driven by the presence of ionospheric delays.
D. Psychas, S. Verhagen
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

GNSS techniques for real-time monitoring of landslides: a review

Satellite Navigation, 2023
Currently, Global Navigation Satellite System (GNSS) Real-Time Kinematic positioning (RTK) and Precise Point Positioning (PPP) techniques are widely employed for real-time monitoring of landslides.
Guanwen Huang, Shi Du, Duo Wang
doaj   +1 more source

A cooperative conjugate gradient method for linear systems permitting multithread implementation of low complexity

, 2012
This paper proposes a generalization of the conjugate gradient (CG) method used to solve the equation $Ax=b$ for a symmetric positive definite matrix $A$ of large size $n$.
Bhaya, Amit, Bliman, Pierre-Alexandre, Niedu, Guilherme, Pazos, Fernando   +3 more
core   +3 more sources

URTK: undifferenced network RTK positioning

GPS Solutions, 2012
Standard network RTK has been widely used since it was proposed in the mid-1990s. Rovers can obtain high-precision estimates of position by resolving double-differenced (DD) ambiguities. The focus of this study is a new undifferenced network RTK method, abbreviated as URTK hereafter, based on undifferenced (UD) observation corrections whose single ...
Zou, X., Ge, M., Tang, W., Shi, C., Liu, J.   +4 more
openaire   +4 more sources

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source