Results 101 to 110 of about 119,552 (307)

Автоматическая генерация аннотаций научных статей на основе больших языковых моделей

Информатика и автоматизация
Предложена концепция автоматизации процесса аннотирования научных материалов (русскоязычных научных статей) и выполнена ее практическая реализация посредством технологий машинного обучения, дообучения больших языковых моделей.
Andrey Golubinskiy, Andrey Tolstykh, Marina Tolstykh   +2 more
doaj   +1 more source

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. [PDF]

, 2016
Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous.
David James, C, Engler, Jane R, Ewald, Andrew J, Gong, Henry, Huillard, Emmanuelle, Koshkakaryan, Gayane, Lindberg, Olle R, McKinney, Andrew, Molinaro, Annette M, Phillips, Joanna J, Robinson, Aaron E, Shieh, Joseph T   +11 more
core   +1 more source

Performance of Single Base RTK GNSS Method versus Network RTK

Earth Sciences Research Journal, 2015
<p>After the late 1990s, GNSS/GPS network RTK technology has become the preferred technique in the world, today widely used in various applications such as monitoring, early warning systems, and mapping and engineering applications. By the end of 2008, the CORS-TR network was being used for engineering applications to determine 3D positions ...
Aykut, Nedim Onur, Gülal, Engin, Akpinar, Burak   +2 more
openaire   +4 more sources

Spatiotemporal Organization of PTK7 Diffusion on Cell Surface Facilitates Tumor Invasion and Migration

Advanced Science, EarlyView.
The spatiotemporal dynamics of protein kinase diffusion govern cellular signaling and functions. Although vital for active receptors, the role of pseudokinase dynamics is unclear. Here, we use single‐molecule tracking to link faster diffusion of pseudokinase PTK7 to increased tumor cell invasion and migration.
Yaohua Li, Tao Pan, Yu Wang, Sainan Guo, Daiquan Chen, Liu Liu, Liwei Wang, Yang Sun, Weihong Tan   +8 more
wiley   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Applicazioni marine del GPS in modalità cinematica (RTK)

GEOmedia, 2016
Applicazioni marine del GPS in modalità cinematica (RTK)
Marina Bertollini
doaj  

Predição de extravasamentos devido à infiltração de águas pluviais em interceptor de esgotamento sanitário de Fortaleza/CE [PDF]

Revista DAE
A entrada indevida de águas pluviais nos sistemas de esgoto sanitário compromete sua eficiência, resultando em extravasamentos e poluição. Este estudo propôs uma metodologia para simulação e otimização de redes coletoras de esgoto, considerando ...
Gustavo Siebra Lopes, João da Silva Cavalcante, Cailiny Darley de Menezes Medeiro, Silvano Porto Pereira, Janine Brandão de Farias Mesquita, Iran Eduardo Lima Neto   +5 more
doaj   +1 more source

Verified Delegated Quantum Computing with One Pure Qubit [PDF]

, 2014
While building a universal quantum computer remains challenging, devices of restricted power such as the so-called one pure qubit model have attracted considerable attention.
Datta, Animesh, Kapourniotis, Theodoros, Kashefi, Elham   +2 more
core  

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. [PDF]

, 2014
A long-standing issue in the field of signal transduction is to understand the cross-talk between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signaling hubs that control eukaryotic cell behavior.
Abagyan, Ruben, Aznar, Nicolas, Ear, Jason, Garcia-Marcos, Mikel, Ghosh, Pradipta, Kufareva, Irina, Lin, Changsheng, Lopez-Sanchez, Inmaculada, Midde, Krishna   +8 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source