Results 81 to 90 of about 85,423 (265)

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Delay Variation Model with RTP Flows Behavior in Accordance with M/D/1 Kendall's Notation

Advances in Electrical and Electronic Engineering, 2010
This paper focuses on the design of a mathematical model of end-to-end delay of a VoIP connection, in particular on a delay variation. It describes all partial delay components and mechanisms, its generation, facilities and its mathematical formulations.
Miroslav Voznak, Michal Halas
doaj  

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of 5‐HT3 Receptor Antagonists: 2026 Update

Clinical Pharmacology &Therapeutics, EarlyView.
5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent
Claire Moore, Melissa S. Bourque, Andreas Halman, José A. G. Agúndez, Cynthia A. Prows, Keiko Hikino, Matthias Schwab, Carolyn J. Oxencis, Dharmisha Chauhan, Meta H.M. Diekstra, Susie E. Long, Gillian C. Bell, Andrea Gaedigk, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Rachel Conyers   +16 more
wiley   +1 more source

Effects of Rhodomyrtus tomentosa Polysaccharides on the Properties of Eleocharis dulcis Starch [PDF]

Shipin Kexue
To investigate the effects and mechanism of Rhodomyrtus tomentosa polysaccharides (RTP) on the starch properties of Eleocharis dulcis, this study examined the effects of adding different concentrations of RTP to E.
DUAN Qiuxia, ZHANG Lin, LI Dingjin, LIU Yan
doaj   +1 more source

Carbon Dots: An Emerging Frontier for Green and Sustainable Civil Engineering Materials

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Traditional civil engineering materials (CE materials) are usually involved with high‐energy consumption during manufacturing, significant maintenance costs, and substantial environmental impacts throughout their life cycles. The progress of nanotechnology is catalyzing a green and sustainable transformation within the field.
Weiwen Hao, Xiaolong Wang, Xiao Chen, Dong Liu, Zhenhui Kang, Cheng Zhu   +5 more
wiley   +1 more source

Flexible organic room‐temperature phosphorescent materials

FlexMat, EarlyView.
This review highlights recent advances in flexible organic room‐temperature phosphorescent (RTP) materials, covering both organic crystal and polymer systems. It discusses strategies to overcome the inherent rigidity and enhance the mechanical flexibility of organic RTP materials, aiming to enable their practical applications in anti‐counterfeiting ...
Bolun Zhang, Xiaokang Shao, Wenjie Yin, Jiahui Xu, Beishen Wu, Zhongfu An, Huifang Shi   +6 more
wiley   +1 more source

New approach methodologies to address population variability and susceptibility

Human Genomics, 2023
Kimberly T. To, Nicole Kleinstreuer, Vasilis Vasiliou, Helena T. Hogberg   +3 more
doaj   +1 more source

How Much Do Psychological Factors Affect Lack of Return to Play After Anterior Cruciate Ligament Reconstruction? A Systematic Review

Orthopaedic Journal of Sports Medicine, 2019
Background: Variables affecting return to sport after anterior cruciate ligament reconstruction (ACLR) are multifactorial. The nonphysical factors germane to successful return to play (RTP) are being increasingly recognized.
Benedict U. Nwachukwu MD, MBA, Joshua Adjei MD, Ryan C. Rauck MD, Jorge Chahla MD, PhD, Kelechi R. Okoroha MD, Nikhil N. Verma MD, Answorth A. Allen MD, Riley J. Williams MD   +7 more
doaj   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

VOIP SYSTEM WITH HIGH AVAILABILITY

Information and Telecommunication Sciences
Background. With the exponential growth of the internet and an increasing number of VoIP (Voice over IP) deployments arose a need to manage and scale the systems in terms of high availability and minimal downtime. Objective.
Сергій Кравчук, Сергій Приймак   +1 more
doaj   +1 more source