Results 61 to 70 of about 17,343 (304)

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Effects of Rhodomyrtus tomentosa Polysaccharides on the Properties of Eleocharis dulcis Starch [PDF]

Shipin Kexue
To investigate the effects and mechanism of Rhodomyrtus tomentosa polysaccharides (RTP) on the starch properties of Eleocharis dulcis, this study examined the effects of adding different concentrations of RTP to E.
DUAN Qiuxia, ZHANG Lin, LI Dingjin, LIU Yan
doaj   +1 more source

ESG Decoupling Phenomenon: A Systematic and Bibliometric Analysis

Business Strategy and the Environment, EarlyView.
ABSTRACT ESG decoupling, defined as the gap between a firm's ESG disclosures and its actual practices, poses a critical challenge to corporate sustainability. Using the PRISMA protocol, 451 articles were selected for a comprehensive bibliometric and systematic literature review to map the intellectual structure and thematic evolution of the research on
Maryam Laeeq, Farida Akhtar, Han Lin Shang   +2 more
wiley   +1 more source

New approach methodologies to address population variability and susceptibility

Human Genomics, 2023
Kimberly T. To, Nicole Kleinstreuer, Vasilis Vasiliou, Helena T. Hogberg   +3 more
doaj   +1 more source

Techno‐Economic Assessment of Biomethane and Biohydrogen Production From Victorian Wheat Straw

Carbon Energy, EarlyView.
Techno‐economic assessment of biomethane and biohydrogen production from Victorian wheat straw. Off‐grid renewable photovoltaic energy with a price down to 0.95 ¢/kWh was applied. Both approaches can make positive profits and negative carbon footprints.
Shuanglong Tan, Ross Swinbourn, Rui Zhang, Yunxia Yang, Xiaojuan Hao, Huile Jin, Chao'en Li, Feng Wang   +7 more
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

VOIP SYSTEM WITH HIGH AVAILABILITY

Information and Telecommunication Sciences
Background. With the exponential growth of the internet and an increasing number of VoIP (Voice over IP) deployments arose a need to manage and scale the systems in terms of high availability and minimal downtime. Objective.
Сергій Кравчук, Сергій Приймак   +1 more
doaj   +1 more source

How Much Do Psychological Factors Affect Lack of Return to Play After Anterior Cruciate Ligament Reconstruction? A Systematic Review

Orthopaedic Journal of Sports Medicine, 2019
Background: Variables affecting return to sport after anterior cruciate ligament reconstruction (ACLR) are multifactorial. The nonphysical factors germane to successful return to play (RTP) are being increasingly recognized.
Benedict U. Nwachukwu MD, MBA, Joshua Adjei MD, Ryan C. Rauck MD, Jorge Chahla MD, PhD, Kelechi R. Okoroha MD, Nikhil N. Verma MD, Answorth A. Allen MD, Riley J. Williams MD   +7 more
doaj   +1 more source

Well‐Defined Nickel Precatalysts: Form, Function, and Application

Chemistry – A European Journal, EarlyView.
This review provides guidance on which nickel precatalysts to choose for a given application or which properties to prioritize in reaction development. A summary of the ease of synthesis, stability, diversity, accessibility, modularity, and general applicability is provided along with a related infographic.
Morgan E. John, George A. Koutsantonis, Reto Dorta, Scott G. Stewart   +3 more
wiley   +1 more source