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Comparative genomics of human rubulavirus 2

Archives of Virology, 2018
Although human rubulavirus 2 (HPIV2) is an important respiratory pathogen, little is known about its molecular epidemiology. We performed a comparative analysis of the full-length genomes of fourteen HPIV2 isolates belonging to different genotypes.
M. Šantak   +3 more
semanticscholar   +4 more sources

Persistence of porcine rubulavirus in experimentally infected boars.

Veterinary Microbiology, 2013
Porcine rubulavirus is the etiological agent of blue eye disease in pigs. In boars, this virus causes orchitis and epididymitis and reduces seminal quality. The objective of this study was to determine the persistence of porcine rubulavirus in experimentally infected boars.
J. F. Rivera-Benítez   +6 more
semanticscholar   +3 more sources

Immunity to porcine rubulavirus infection in adult swine.

Veterinary Immunology and Immunopathology, 1998
The immune response against the porcine rubulavirus was analyzed in experimentally infected adult pigs. High titers of virus neutralizing and hemagglutinating inhibitory antibodies were identified in infected animals. The antibody specificity was directed towards HN, M, and NP rubula virion proteins; immunodominance of HN proteins was demonstrated ...
J. Hernández   +5 more
semanticscholar   +3 more sources

Molecular characterisation of Porcine rubulavirus (PorPV) isolates from different outbreaks in Mexico

Virus Genes, 2016
Since the report of the initial outbreak of Porcine rubulavirus (PorPV) infection in pigs, only one full-length genome from 1984 (PorPV-LPMV/1984) has been characterised. To investigate the overall genetic variation, full-length gene nucleotide sequences of current PorPV isolates were obtained from different clinical cases of infected swine.
S. Cuevas-Romero   +7 more
semanticscholar   +3 more sources

Tetherin antagonism by V proteins is a common trait among the genus Rubulavirus

Medical Microbiology and Immunology, 2017
Tetherin (BST-2/CD317/HM1.24) is an anti-viral factor that restricts the budding of several enveloped viruses. Most of these viruses have evolved to encode tetherin antagonists. Our previous study demonstrated that the growth of human parainfluenza virus type 2 (hPIV-2), a member of the genus Rubulavirus in the family Paramyxoviridae, was inhibited by ...
K. Ohta   +3 more
semanticscholar   +3 more sources

Neuraminidase activity of blue eye disease porcine rubulavirus: Specificity, affinity and inhibition studies.

Research in Veterinary Science, 2017
Porcine rubulavirus (PorPV), also known as La Piedad Michoacan Virus (LPMV) causes encephalitis and reproductive failure in newborn and adult pigs, respectively. The hemagglutinin-neuraminidase (HN) glycoprotein is the most exposed and antigenic of the virus proteins. HN plays central roles in PorPV infection; i.e., it recognizes sialic acid-containing
G. Santos-López   +9 more
semanticscholar   +4 more sources

Experimental porcine rubulavirus (La Piedad-Michoacan virus) infection in pregnant gilts.

Journal of Comparative Pathology, 2004
Porcine rubulavirus (La Piedad-Michoacan virus) (PoRV-LPMV) is a member of the Paramyxoviridae family that causes encephalitis in young piglets and infertility in adult sows and boars. Infertility in sows naturally infected by PoRV-LPMV is characterized by an increased number of returns to oestrus, stillbirths and mummified fetuses. In this study, nine
P. Hernández-Jáuregui   +4 more
semanticscholar   +3 more sources

Full-genome sequencing and phylogenetic analysis of four neurovirulent Mexican isolates of porcine rubulavirus

Archives of Virology, 2017
We report the complete genome sequences of four neurovirulent isolates of porcine rubulavirus (PorPV) from 2015 and one historical PorPV isolate from 1984 obtained by next-generation sequencing. A phylogenetic tree constructed using the individual sequences of the complete HN genes of the 2015 isolates and other historical sequences deposited in the ...
Ali A. Garcia-Barrera   +5 more
semanticscholar   +3 more sources

Cloning, expression and characterization of potential immunogenic recombinant hemagglutinin-neuraminidase protein of Porcine rubulavirus.

Protein Expression and Purification, 2016
Blue eye disease caused by Porcine rubulavirus (PorPV) is an endemic viral infection of swine causing neurological and respiratory disease in piglets, and reproductive failure in sows and boars. The hemagglutinin-neuraminidase (HN) glycoprotein of PorPV is the most abundant component in the viral envelope and the main target of the immune response in ...
Julieta Sandra Cuevas-Romero   +7 more
semanticscholar   +3 more sources

Lesions in the reproductive tract of boars experimentally infected with porcine rubulavirus.

Journal of Comparative Pathology, 1997
"Blue eye" disease of pigs in Mexico is caused by porcine rubulavirus and characterized by infertility in sows and boars, nervous signs in young pigs, and corneal opacity in pigs of all ages. The pathogenesis of reproductive tract lesions in rubulavirus-infected boars has not previously been investigated.
H. Ramírez-Mendoza   +9 more
semanticscholar   +3 more sources

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