Results 1 to 10 of about 42,387 (114)

Cellular vimentin regulates the infectivity of Newcastle disease virus through targeting of the HN protein [PDF]

Veterinary Research, 2023
The haemagglutinin-neuraminidase (HN) protein plays a crucial role in the infectivity and virulence of Newcastle disease virus (NDV). In a previous study, the mutant HN protein was identified as a crucial virulence factor for the velogenic variant NDV ...
Xiaolong Lu, Kaituo Liu, Yu Chen, Ruyi Gao, Zenglei Hu, Jiao Hu, Min Gu, Shunlin Hu, Chan Ding, Xinan Jiao, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu   +12 more
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Residues 315 and 369 in HN Protein Contribute to the Thermostability of Newcastle Disease Virus [PDF]

Frontiers in Microbiology, 2020
Thermostable Newcastle disease virus (NDV) vaccines have been widely used in areas where a “cold-chain” is not reliable. However, the molecular mechanism of NDV thermostability remains poorly understood.
Baoyang Ruan, Xiaorong Zhang, Chengcheng Zhang, Pengyu Du, Chengcheng Meng, Mengjiao Guo, Yantao Wu, Yongzhong Cao   +7 more
doaj   +2 more sources

Identification of a new amino acid mutation in the HN protein of NDV involved in pathogenicity [PDF]

Veterinary Research, 2021
The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are viral entry proteins and are recognized as the major virulence determinants. Previously, a lentogenic NDV virus (CE16) was derived from a mesogenic strain (
Xi Chen, Yanqing Jia, Ning Wei, Chao Ye, Huafang Hao, Sa Xiao, Xinglong Wang, Haijin Liu, Zengqi Yang   +8 more
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Generation, characterization and epitope mapping of monoclonal antibody 4H3 specific to the HN protein of pigeon paramyxovirus type 1 (PPMV-1) [PDF]

Frontiers in Microbiology
Pigeon Newcastle disease (PND), caused by pigeon paramyxovirus type 1 (PPMV-1), is an acute, highly contagious disease that induces neurological symptoms and gastrointestinal disorders in pigeons, posing substantial economic risks to the global pigeon ...
Xu Wang, Hongfeng Ren, Pei Li, Zhonglin Huang, Xing Li, Yang Wang, Yang Wang, Yang Li, Libin Liang, Junping Li   +9 more
doaj   +2 more sources

Roles of the highly conserved amino acids in the second receptor binding site of the Newcastle disease virus HN protein [PDF]

Virology Journal, 2019
Background The paramyxovirus haemagglutinin-neuraminidase (HN) is a multifunctional protein that is responsible for attachment to receptors, removal of receptors from infected cells to prevent viral self-aggregation (neuraminidase, NA) and fusion ...
Yaqing Liu, Miaomiao Chi, Ying Liu, Hongling Wen, Li Zhao, Yanyan Song, Na Liu, Zhiyu Wang   +7 more
doaj   +2 more sources

Nucleotide sequence characterization, amino acid variations and 3D structural analysis of HN protein of the NDV VIId genotype [PDF]

Veterinary Medicine and Science
Background Haemagglutinin–neuraminidase (HN) is one of the membrane proteins of Newcastle disease virus (NDV) that plays a significant role during host viral infection.
Amin Tavassoli, Safoura Soleymani, Mohammad Reza Housaindokht   +2 more
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Biological Significance of Dual Mutations A494D and E495K of the Genotype III Newcastle Disease Virus Hemagglutinin-Neuraminidase In Vitro and In Vivo

Viruses, 2022
As a multifunctional protein, the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is involved in various biological functions.
Xiaolong Lu, Tiansong Zhan, Kaituo Liu, Yu Chen, Zenglei Hu, Jiao Hu, Min Gu, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Xiufan Liu   +10 more
doaj   +1 more source

The effect of ultrasound assisted enzymatic hydrolysis on the physicochemical properties and flavor characteristics of protein peptides from Harpodon nehereus

Shipin yu jixie, 2023
Objective: This study aimed to solve the problems of low freshness, heavy bitterness, and poor flavor of protein peptides hydrolyzed by enzymes of Harpodon nehereus （HN）. Methods: Ultrasound assisted enzymatic hydrolysis method was used to prepare the HN
LU Jianghui, CHEN Yuewen, FU Jingjing, LONG Yongjie   +3 more
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Expression and characterization of hemagglutinin–neuraminidase protein from Newcastle disease virus in Bacillus subtilis WB800

Journal of Genetic Engineering and Biotechnology, 2022
Background Newcastle disease virus (NDV) belongs to the genus Avaluvirus and Paramyxoviridae family, and it can cause acute, highly contagious Newcastle disease in poultry.
Mohammadreza Shafaati, Masoud Ghorbani, Minoo Mahmoodi, Mostafa Ebadi, Reza Jalalirad   +4 more
doaj   +1 more source

Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy

Frontiers in Genetics, 2021
Hypertensive nephropathy (HN), mainly caused by chronic hypertension, is one of the major causes of end-stage renal disease. However, the pathogenesis of HN remains unclarified, and there is an urgent need for improved treatments.
Shilong You, Jiaqi Xu, Boquan Wu, Shaojun Wu, Ying Zhang, Yingxian Sun, Naijin Zhang   +6 more
doaj   +1 more source