Results 21 to 30 of about 138,247 (296)

Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F

Toxins, 2023
Botulinum neurotoxins (BoNTs) can cause nerve paralysis syndrome in mammals and other vertebrates. BoNTs are the most toxic biotoxins known and are classified as Class A biological warfare agents. BoNTs are mainly divided into seven serotypes A-G and new
Zhiying Li, Bolin Li, Jiansheng Lu, Xuyang Liu, Xiao Tan, Rong Wang, Peng Du, Shuo Yu, Qing Xu, Xiaobin Pang, Yunzhou Yu, Zhixin Yang   +11 more
doaj   +1 more source

Triggering of Human Parainfluenza Virus 3 Fusion Protein (F) by the Hemagglutinin-Neuraminidase (HN) Protein: an HN Mutation Diminishes the Rate of F Activation and Fusion [PDF]

Journal of Virology, 2003
ABSTRACT For human parainfluenza virus type 3 and many other paramyxoviruses, membrane fusion mediated by the fusion protein (F) has a stringent requirement for the presence of the homotypic hemagglutinin-neuraminidase protein (HN). With the goal of gaining further insight into the role of HN in the fusion process, we developed a simple ...
Porotto, Matteo, Murrell, Matthew, Greengard, Olga, Moscona, Anne   +3 more
openaire   +3 more sources

MAS NMR detection of hydrogen bonds for protein secondary structure characterization [PDF]

, 2020
Hydrogen bonds are essential for protein structure and function, making experimental access to long-range interactions between amide protons and heteroatoms invaluable. Here we show that measuring distance restraints involving backbone hydrogen atoms and
Friedrich, Daniel, Nieuwkoop, Andrew J., Oschkinat, Hartmut, Perodeau, Jacqueline   +3 more
core   +1 more source

Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain. [PDF]

PLoS Pathogens, 2013
Paramyxoviruses cause a wide variety of human and animal diseases. They infect host cells using the coordinated action of two surface glycoproteins, the receptor binding protein (HN, H, or G) and the fusion protein (F). HN binds sialic acid on host cells
Brett D Welch, Ping Yuan, Sayantan Bose, Christopher A Kors, Robert A Lamb, Theodore S Jardetzky   +5 more
doaj   +1 more source

The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration

Frontiers in Cell and Developmental Biology, 2022
Humanin (HN) belongs to a member of mitochondrial-derived peptides (MDPs) which are encoded by mitochondrial genes. HN shares sequence homology with thirteen HN-like proteins, named MTRNR2L1 to MTRNR2L13, which encompass 24–28 amino acid residues in ...
Sipin Zhu, Xiaoyong Hu, Samuel Bennett, Jiake Xu, Yuliang Mai   +4 more
doaj   +1 more source

Paramyxovirus Fusion (F) Protein and Hemagglutinin–Neuraminidase (HN) Protein Interactions: Intracellular Retention of F and HN Does Not Affect Transport of the Homotypic HN or F Protein

Virology, 1997
To investigate a possible intracellular coassociation of the paramyxovirus simian virus 5 (SV5) and human parainfluenza virus type 3 (HPIV-3) fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins in a living cell, without resorting to chemical crosslinking and antibody coimmunoprecipitation, we tagged the cytoplasmic N-terminus of SV5 HN with a
Paterson, Reay G., Johnson, Michael L., Lamb, Robert A.   +2 more
openaire   +2 more sources

Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy

mBio, 2020
The receptor binding protein of parainfluenza virus, hemagglutinin-neuraminidase (HN), is responsible for actively triggering the viral fusion protein (F) to undergo a conformational change leading to insertion into the target cell and fusion of the ...
T. C. Marcink, E. Yariv, K. Rybkina, V. Más, F. T. Bovier, A. des Georges, A. L. Greninger, C. A. Alabi, M. Porotto, N. Ben-Tal, A. Moscona   +10 more
doaj   +1 more source

Direct interaction of the molecular chaperone GRP78/BiP with the Newcastle disease virus hemagglutinin-neuraminidase protein plays a vital role in viral attachment to and infection of culture cells

Frontiers in Immunology, 2023
IntroductionGlucose Regulated Proteins/Binding protein (GRP78/Bip), a representative molecular chaperone, effectively influences and actively participates in the replication processes of many viruses.
Chenxin Han, Chenxin Han, Ziwei Xie, Ziwei Xie, Yadi Lv, Yadi Lv, Dingxiang Liu, Dingxiang Liu, Dingxiang Liu, Ruiai Chen, Ruiai Chen   +10 more
doaj   +1 more source

Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

Frontiers in Endocrinology, 2021
Physiological reactive oxygen species (ROS) are important regulators of intercellular signal transduction. Oxidative and antioxidation systems maintain a dynamic balance under physiological conditions. Increases in ROS levels destroy the dynamic balance,
He Cai, Yunxia Liu, Hongbo Men, Yang Zheng   +3 more
doaj   +1 more source

Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy [PDF]

Jichu yixue yu linchuang, 2023
Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia, leading to hyperuricemia-associated renal abnormalities. The present review sheds light on the mechanistic aspects pertaining to HN, emphasizing the role of nucleotide ...
DAI Zhixin, WANG Yumin
doaj   +1 more source