Results 21 to 30 of about 42,486 (210)

Direct interaction of the molecular chaperone GRP78/BiP with the Newcastle disease virus hemagglutinin-neuraminidase protein plays a vital role in viral attachment to and infection of culture cells

Frontiers in Immunology, 2023
IntroductionGlucose Regulated Proteins/Binding protein (GRP78/Bip), a representative molecular chaperone, effectively influences and actively participates in the replication processes of many viruses.
Chenxin Han, Chenxin Han, Ziwei Xie, Ziwei Xie, Yadi Lv, Yadi Lv, Dingxiang Liu, Dingxiang Liu, Dingxiang Liu, Ruiai Chen, Ruiai Chen   +10 more
doaj   +1 more source

Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

Frontiers in Endocrinology, 2021
Physiological reactive oxygen species (ROS) are important regulators of intercellular signal transduction. Oxidative and antioxidation systems maintain a dynamic balance under physiological conditions. Increases in ROS levels destroy the dynamic balance,
He Cai, Yunxia Liu, Hongbo Men, Yang Zheng   +3 more
doaj   +1 more source

Different Origins of Newcastle Disease Virus Hemagglutinin-Neuraminidase Protein Modulate the Replication Efficiency and Pathogenicity of the Virus

Frontiers in Microbiology, 2017
To investigate the exact effects of different origins of Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein to the biological characteristics of the virus, we systematically studied the correlation between the HN protein and NDV ...
Ji-hui Jin, Jin-long Cheng, Zi-rong He, Ying-chao Ren, Xiao-hui Yu, Yang Song, Hui-ming Yang, Yan-ling Yang, Tong Liu, Guo-zhong Zhang, Guo-zhong Zhang   +10 more
doaj   +1 more source

Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy [PDF]

Jichu yixue yu linchuang, 2023
Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia, leading to hyperuricemia-associated renal abnormalities. The present review sheds light on the mechanistic aspects pertaining to HN, emphasizing the role of nucleotide ...
DAI Zhixin, WANG Yumin
doaj   +1 more source

Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

mBio, 2015
In order to deliver their genetic material to host cells during infection, enveloped viruses use specialized proteins on their surfaces that bind cellular receptors and induce fusion of the viral and host membranes.
Long Gui, Eric M. Jurgens, Jamie L. Ebner, Matteo Porotto, Anne Moscona, Kelly K. Lee   +5 more
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Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

mBio, 2013
Paramyxoviruses, enveloped RNA viruses that include human parainfluenza virus type 3 (HPIV3), cause the majority of childhood viral pneumonia. HPIV3 infection starts when the viral receptor-binding protein engages sialic acid receptors in the lung and ...
Rui Xu, Samantha G. Palmer, Matteo Porotto, Laura M. Palermo, Stefan Niewiesk, Ian A. Wilson, Anne Moscona   +6 more
doaj   +1 more source

Single-Dose Vaccination of Recombinant Chimeric Newcastle Disease Virus (NDV) LaSota Vaccine Strain Expressing Infectious Bursal Disease Virus (IBDV) VP2 Gene Provides Full Protection against Genotype VII NDV and IBDV Challenge

Vaccines, 2021
Newcastle disease virus (NDV) and infectious bursal disease virus (IBDV) are the two most important and widespread viruses causing huge economic losses in the global poultry industry.
Qilong Qiao, Mingzhen Song, Congcong Song, Yihang Zhang, Xiangdong Wang, Qing Huang, Baiyu Wang, Panpan Yang, Shiyi Zhao, Yongtao Li, Zeng Wang, Jun Zhao   +11 more
doaj   +1 more source

Functional EL-HN Fragment as a Potent Candidate Vaccine for the Prevention of Botulinum Neurotoxin Serotype E

Toxins, 2022
Clostridium botulinum produces botulinum neurotoxin (BoNT), which is the most toxic known protein and the causative agent of human botulism. BoNTs have similar structures and functions, comprising three functional domains: catalytic domain (L ...
Zhen Li, Jiansheng Lu, Xiao Tan, Rong Wang, Qing Xu, Yunzhou Yu, Zhixin Yang   +6 more
doaj   +1 more source

Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence. [PDF]

PLoS Pathogens, 2012
Paramyxovirus hemagglutinin-neuraminidase (HN) plays roles in viral entry and maturation, including binding to sialic acid receptors, activation of the F protein to drive membrane fusion, and enabling virion release during virus budding.
Ping Yuan, Reay G Paterson, George P Leser, Robert A Lamb, Theodore S Jardetzky   +4 more
doaj   +1 more source

Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly. [PDF]

PLoS ONE, 2013
Interactions between viral glycoproteins, matrix protein and nucleocapsid sustain assembly of parainfluenza viruses at the plasma membrane. Although the protein interactions required for virion formation are considered to be highly specific, virions ...
Raychel Stone, Toru Takimoto
doaj   +1 more source