Toxins, 2022 Clostridium botulinum produces botulinum neurotoxin (BoNT), which is the most toxic known protein and the causative agent of human botulism. BoNTs have similar structures and functions, comprising three functional domains: catalytic domain (L ...
Zhen Li +6 more
doaj +1 more source
Vaccines, 2021 Newcastle disease virus (NDV) and infectious bursal disease virus (IBDV) are the two most important and widespread viruses causing huge economic losses in the global poultry industry.
Qilong Qiao +11 more
doaj +1 more source
Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly. [PDF]
PLoS ONE, 2013 Interactions between viral glycoproteins, matrix protein and nucleocapsid sustain assembly of parainfluenza viruses at the plasma membrane. Although the protein interactions required for virion formation are considered to be highly specific, virions ...
Raychel Stone, Toru Takimoto
doaj +1 more source
HN-PPISP: a hybrid network based on MLP-Mixer for protein–protein interaction site prediction
Briefings in Bioinformatics, 2022 AbstractMotivationBiological experimental approaches to protein–protein interaction (PPI) site prediction are critical for understanding the mechanisms of biochemical processes but are time-consuming and laborious. With the development of Deep Learning (DL) techniques, the most popular Convolutional Neural Networks (CNN)-based methods have been ...
Yan Kang 0003 +6 more
openaire +2 more sources
Comparing open and closed molecular self-assembly [PDF]
, 2014 We study theoretically in the present work the self-assembly of molecules in an open system, which is fed by monomers and depleted in partial or complete clusters. Such a scenario is likely to occur for example in the context of viral self-assembly.
Castelnovo, Martin +2 more
core +6 more sources
Enzymatic functionalization of carbon-hydrogen bonds [PDF]
, 2011 The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds continues to progress at a rapid pace due to the significant economic and environmental benefits of these transformations over traditional synthetic methods.
Arnold, Frances H. +2 more
core +1 more source
Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence. [PDF]
PLoS Pathogens, 2012 Paramyxovirus hemagglutinin-neuraminidase (HN) plays roles in viral entry and maturation, including binding to sialic acid receptors, activation of the F protein to drive membrane fusion, and enabling virion release during virus budding.
Ping Yuan +4 more
doaj +1 more source
Synthetic Gene Circuits: Design with Directed Evolution [PDF]
, 2007 Synthetic circuits offer great promise for generating insights into nature's underlying design principles or forward engineering novel biotechnology applications. However, construction of these circuits is not straightforward.
Arnold, Frances H., Haseltine, Eric L.
core +1 more source
Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance [PDF]
, 2014 Background: In cancer cells, apoptosis is an important mechanism that influences the outcome of chemotherapy and the development of chemoresistance.
Ebrahimifard, F. +5 more
core +1 more source
Cloning and Expression of the Haemagglutinin-neuraminidase Gene of Newcastle Disease Virus Strain Af2240 Lnto Eschericia Coli [PDF]
, 1997 A 1815 bp sequence of the open reading frame (ORF) of the haemagglutinin-neuraminidase (HN) gene of velogenic-viscerotropic Newcastle disease virus (NDV) strain AF2240 was amplified reaction (PCR) using primers SI (5'CACCAATAGCAGACTCCA3') and S2 (5 ...
Sudin, Sudani
core