Results 31 to 40 of about 138,247 (296)
A Mutation in the Stalk of the Newcastle Disease Virus Hemagglutinin-Neuraminidase (HN) Protein Prevents Triggering of the F Protein despite Allowing Efficient HN-F Complex Formation [PDF]
Journal of Virology, 2013 ABSTRACT Newcastle disease virus (NDV)-induced membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins. Substitutions for NDV HN stalk residues A89, L90, and L94 block fusion by modulating formation of the HN-F complex.
Mirza, Anne M., Iorio, Ronald M.
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Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy [PDF]
, 2011 Background To investigate the relationship between the selective pressure and the sequence variation of the hemagglutinin-neuraminidase (HN) protein, we performed the positive selection analysis by estimating the ratio of non-synonymous to ...
Min Gu +6 more
core +1 more source
Frontiers in Microbiology, 2017 To investigate the exact effects of different origins of Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein to the biological characteristics of the virus, we systematically studied the correlation between the HN protein and NDV ...
Ji-hui Jin +10 more
doaj +1 more source
Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus
PLOS ONE, 2020 Porcine rubulavirus (PRV), which belongs to the family Paramyxoviridae, causes blue eye disease in pigs, characterized by encephalitis and reproductive failure in newborn and adult pigs, respectively. There is no effective treatment against PRV and no information on the effectiveness of the available vaccines.
Luis I. Siañez-Estrada +5 more
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Newcastle Disease Virus HN Protein Alters the Conformation of the F Protein at Cell Surfaces [PDF]
Journal of Virology, 2002 ABSTRACT Conformational changes in the Newcastle disease virus (NDV) fusion (F) protein during activation of fusion and the role of HN protein in these changes were characterized with a polyclonal antibody. This antibody was raised against a peptide with the sequence of the amino-terminal half of the F protein HR1 domain.
Cullen, Lori McGinnes +2 more
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mBio, 2015 In order to deliver their genetic material to host cells during infection, enveloped viruses use specialized proteins on their surfaces that bind cellular receptors and induce fusion of the viral and host membranes.
Long Gui +5 more
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Antigenic and genetic variation of the HN protein of mumps virus strains
Journal of General Virology, 1996 The relationships between different strains of mumps virus were established by determination of the sequence of the HN gene. They closely resemble those established from other portions of the genome, suggesting that the viruses are not recombinants over the areas examined.
P J, Yates, M A, Afzal, P D, Minor
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Bioengineering models of cell signaling [PDF]
, 2000 Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therapeutics and understanding effects of environmental agents on physiological systems may be derived from a mechanistic understanding of underlying signaling ...
Asthagiri, Anand R. +1 more
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NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification [PDF]
, 2005 The non-enzymatic reaction between reducing sugars and long-lived proteins in vivo results in the formation of glycation and advanced glycation end products, which alter the properties of proteins including charge, helicity, and their tendency to ...
Howard, Mark J. +1 more
core +1 more source
mBio, 2013 Paramyxoviruses, enveloped RNA viruses that include human parainfluenza virus type 3 (HPIV3), cause the majority of childhood viral pneumonia. HPIV3 infection starts when the viral receptor-binding protein engages sialic acid receptors in the lung and ...
Rui Xu +6 more
doaj +1 more source