Results 51 to 60 of about 138,247 (296)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Determination of HN,H? and HN,C? coupling constants in 13C, 15N-labeled proteins

Journal of Biomolecular NMR, 1994
Sensitive three-dimensional NMR experiments, based on the E.COSY principle, are presented for the measurement of the (3)J(H(N),H(α)) and (3)J(H(N),C') coupling constants in uniformly (13)C- and (15)N-labeled proteins. They employ gradient coherence selection in combination with the sensitivity enhancement method in HSQC-type spectra (Cavanagh et al ...
Weisemann, R., Rüterjans, H., Schwalbe, H., Schleucher, J., Bermel, W., Griesinger, C.   +5 more
openaire   +3 more sources

Biophysical Studies Of The Hn-s Protein From Xyllela fastidiosa And Dna [PDF]

Biophysical Journal, 2009
The nucleoid-associated protein H-NS is a major component of the bacterial nucleoid, involved in DNA compaction and transcription regulation. Extensive studies on the biological functions demonstrated that H-NS plays a role in the regulation of many genes on the Escherichia coli chromosome, and represses the expression of a variety of proteins at the ...
Zeri, Ana-Carolina, Rosseli, Luciana K., Sforça, Maurício L., Slovic, Avram, Sassonia, Rogério C., Souza, Anete P.   +5 more
openaire   +1 more source

Production of Recombinant Envelope Proteins of Newcastle Disease Virus in Escherichia Coli and Analysis of Their Immunological Properties [PDF]

, 2005
Newcastle disease virus (NDV) is the causative agent of the Newcastle disease (ND) thatremains as a major threat to the world poultry industry. The virus belongs to the family Paramyxoviridae and genus Avulavirus, infects more than 236 avian species ...
Wong, Sing King
core  

Unraveling the senses of Phytophthora; leads to novel control strategies? [PDF]

, 2009
Oomycetes cause devastating diseases on plants and animals. They cause major yield losses in many crop plants and their control heavily depends on agrochemicals. This is certainly true for the potato late blight pathogen Phytophthora infestans.
Govers, F., Meijer, H.J.G., Raaijmakers, J.M., Tran, H., Wagemakers, L.   +4 more
core   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism

mBio, 2019
Paramyxoviruses, specifically, the childhood pathogen human parainfluenza virus type 3, are internalized into host cells following fusion between the viral and target cell membranes.
S. F. Bottom-Tanzer, K. Rybkina, J. N. Bell, C. A. Alabi, C. Mathieu, M. Lu, S. Biswas, M. Vasquez, M. Porotto, J. A. Melero, V. Más, A. Moscona   +11 more
doaj   +1 more source

Thermostability and Protein Studies of Newcastle Disease Virus [PDF]

, 1995
The heat stability of four strains of Newcastle disease virus (NDV) belonging to three different pathotypes were studied. The strains were the lentogenic V4 and its heat stable variant V4-UPM, the mesogenic S strain and the velogenic strain AF2240 ...
Hassan, Zuridah
core  

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]

, 2010
The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr, Bock, David J. Stephens, Derby, Doherty, Erickson, Falnes, Feng, Feng, Fiebiger, Frédéric Boal, Fuchs, Gewald, Girod, Guetzoyan, Guy J. Clarkson, Helms, Herold, Hey, Hill, J. Michael Lord, Jackson, Johannes, Johannes, Johannes, Klausner, Lieu, Linstedt, Lu, Lucie J. Guetzoyan, Lynne M. Roberts, Macia, McKenzie, Monier, Nambiar, Nieland, Pavelka, Pelish, Perez-Victoria, Peyroche, Pirali, Plourde, Ponnambalam, Renault, Robert A. Spooner, Rostovtsev, Saenz, Saenz, Sandvig, Shima, Shin, Shin, Spooner, Spooner, Stechmann, Tai, Tsai, Viaud, Volpicelli-Daley, Wells, White, Wilcke, Yarrow, Yoshino, Zeghouf, Zhang, Zhao, Zolov   +67 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source