Results 51 to 60 of about 323,715 (337)

La traversée fantôme : Ghost Milk de Iain Sinclair

open access: yesÉtudes Britanniques Contemporaines, 2015
In Ghost Milk, published on the eve of the London Olympics in 2011, Iain Sinclair goes against public consensus to defend the post-industrial East-End, sacrificed to build computer-engineered olympic superstructures such as the huge stadium, highway and ...
Catherine Lanone
doaj   +1 more source

Computing ruin probability and minimum initial capital by simulation [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2017
In this paper, we propose a new approximation method to obtain the ruin probability by modifying the PollaczekKhinchin approximation. The proposed approximation is simpler and requires fewer assumptions than other methods mentioned in the literature ...
Pawat Paksaranuwat, Samruam Chongcharoen
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

The ruin revisited [PDF]

open access: yes, 2010
A chapter which explores the role of ruins within contemporary socety and the reception associated with them. In particular, it highlights the important ways in which social time is configured around the recovery of ruins from the past, focusing on the ...
Hetherington, Kevin
core  

A Note on Applications of Stochastic Ordering to Control Problems in Insurance and Finance

open access: yes, 2013
We consider a controlled diffusion process $(X_t)_{t\ge 0}$ where the controller is allowed to choose the drift $\mu_t$ and the volatility $\sigma_t$ from a set $\K(x) \subset \R\times (0,\infty)$ when $X_t=x$.
Bauerle, Nicole, Bayraktar, Erhan
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Ruina historyczna – ingerencje i ich uwarunkowania

open access: yesOchrona Dziedzictwa Kulturowego, 2020
Skuteczna ochrona historycznych ruin, podobnie jak innych zabytków, uwarunkowana jest współczesnym użytkowaniem. Dostosowanie ruin do standardów użytkowych wymusza ich konserwację profilaktyczną i zachowawczą, ale też konieczne dla nowych funkcji ...
Piotr Molski
doaj   +1 more source

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